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Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma.
CONCLUSION: We provide new evidence that TROP2 is epigenetically down-regulated and operates as a negative regulator of cell proliferation and migration in liver fluke-associated CCA. PMID: 31320172 [PubMed]
Source: Annals of Hepatology - July 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction
Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction is modified to maintain barrier function may provide avenues for treatment of IBD. We have previously shown that the apical addition of serine proteases to intestinal epithelial cell lines causes a rapid and sustained increase in transepithelial electrical resistance (TER), but the mechanisms are unknown. We hypothesized that serine proteases increase barrier function through trafficking and insertion of tight junction proteins into the membrane, and this could enhan...
Source: AJP: Gastrointestinal and Liver Physiology - August 31, 2016 Category: Gastroenterology Authors: Ronaghan, N. J., Shang, J., Iablokov, V., Zaheer, R., Colarusso, P., Turner, J. R., MacNaughton, W. K. Tags: EPITHELIAL BIOLOGY AND SECRETION Source Type: research

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway
Conclusions We identified a novel CRC regulatory circuit involving the miR-519-Orai1 axis, and dysfunction of this drives diverse aspects of CRC pathogenesis.
Source: Digestive Diseases and Sciences - January 20, 2016 Category: Gastroenterology Source Type: research

Suppression of trophoblast cell surface antigen 2 enhances proliferation and migration in liver fluke-associated cholangiocarcinoma.
CONCLUSION: We provide new evidence that TROP2 is epigenetically down-regulated and operates as a negative regulator of cell proliferation and migration in liver fluke-associated CCA. PMID: 26626643 [PubMed - in process]
Source: Annals of Hepatology - December 6, 2015 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca2+ in FLO cells, an increase that is blocked by Ca2+-free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of intrac...
Source: AJP: Gastrointestinal and Liver Physiology - May 15, 2014 Category: Gastroenterology Authors: Li, D., Cao, W. Tags: CANCER BIOLOGY Source Type: research

Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca(2+) in FLO cells, an increase which is blocked by Ca(2+) free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of i...
Source: Am J Physiol Gastroi... - April 3, 2014 Category: Gastroenterology Authors: Li D, Cao W Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research