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Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to colorectal visceral pain in adult mice with neonatal maternal deprivation
CONCLUSIONS: This study suggested that overexpression of Rab27a increased exosome secretion in ACC neurons, thus contributing to visceral hyperalgesia in NMD mice.PMID:37529842 | DOI:10.1152/ajpgi.00029.2023
Source: Am J Physiol Gastroi... - August 2, 2023 Category: Gastroenterology Authors: Qian Sun Rui-Xia Weng Jia-Hui Li Yong-Chang Li Ji-Tian Xu Rui Li Xiaomin Lu Guang-Yin Xu Source Type: research

Role of mast cell-miR-490-5p in irritable bowel syndrome.
CONCLUSION: miR-490-5p plays a vital role in the pathogenesis of irritable bowel syndrome by affecting mast cell proliferation and apoptosis; with down-regulation of miR-490-5p, the mRNA level of mast cell tryptase and PAR-2 increased, and the protein level increased, but the difference was not statistically significant. PMID: 28104984 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - January 6, 2017 Category: Gastroenterology Authors: Ren HX, Zhang FC, Luo HS, Zhang G, Liang LX Tags: World J Gastroenterol Source Type: research

Vagal afferent‐dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA‐NR2B receptors in rats
Conclusions & InferencesThe pronociception induced by systemic CCK, which is vagal afferent‐dependent, requires activation of CeA NMDA‐NR2B receptors. Systemic CCK augments visceral pain response to CRD stimulation in rats. This effect is dependent on vagal afferent activity and the downstream CeA NMDA‐NR2B receptor activation.
Source: Neurogastroenterology and Motility - July 22, 2015 Category: Gastroenterology Authors: E. M. Wang, W. T. Li, X. J. Yan, X. Chen, Q. Liu, C. C. Feng, Z. J. Cao, J. Y. Fang, S. L. Chen Tags: Original Article Source Type: research