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siRNA-Mediated Silencing of doublesex during Female Development of the Dengue Vector Mosquito Aedes aegypti
by Keshava Mysore, Longhua Sun, Michael Tomchaney, Gwyneth Sullivan, Haley Adams, Andres S. Piscoya, David W. Severson, Zainulabeuddin Syed, Molly Duman-Scheel The development of sex-specific traits, including the female-specific ability to bite humans and vector disease, is critical for vector mosquito reproduction and pathogen transmission. Doublesex (Dsx), a terminal transcription factor in the sex determination pathway, is known to regulate sex-specific gene expression during development of the dengue fever vector mosquito Aedes aegypti. Here, the effects of developmental siRNA-mediated dsx silencing were assessed in ...
Source: PLoS Neglected Tropical Diseases - November 6, 2015 Category: Tropical Medicine Authors: Keshava Mysore et al. Source Type: research

Expression of MAPK1 in cervical cancer and effect of MAPK1 gene silencing on epithelial-mesenchymal transition, invasion and metastasis
Conclusions Because of the high expression of MAPK1 in the cervical cancer tissue, the interference in the expression of MAPK1 can significantly inhibit the invasion and metastasis of cervical cancer HeLa cells, which is related to the interference in the expression of MMPs/TIMP and Snail-mediated generation of EMT.
Source: Asian Pacific Journal of Tropical Medicine - October 9, 2015 Category: Tropical Medicine Source Type: research

Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells
Conclusions The inhibition of Wisp-1 expression can reduce the proliferation, migration and adhesion of mouse hepatocellular carcinoma cells, which is related to the AKT/glycogen synthase kinase-3β pathway. Wisp-1 gene may be the potential target to cure the hepatocellular carcinoma.
Source: Asian Pacific Journal of Tropical Medicine - October 4, 2015 Category: Tropical Medicine Source Type: research

Expression of HIP/PAP in hepatocellular carcinoma and effect of siRNA on migration and invasion in HCC cells
Conclusions HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
Source: Asian Pacific Journal of Tropical Medicine - September 25, 2015 Category: Tropical Medicine Source Type: research

HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells
Conclusions Carcinoma HepG2 cell transfected high expression of HSP can promote the transformation of EMT, improve the expression of Vimentin, reduce the expression of E-cadherin, and inhibit apoptosis of cancer stem cells, which improve the invasive ability of cancer of the liver cells. While hsp-siRNA group presents opposite results. In summary, the expression of HSP is closely related to the occurrence, development and invasion of cancer of the liver tissue.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Effects of gene silencing of CypB on gastric cancer cells
Conclusions Gene silencing of CypB decreases gastric cancer cells proliferation and in vivo tumorigenesis. These findings indiccate CypB could be a potential biomarker and therapeutic target for gastric cancer.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Effect of survivin siRNA on biological behaviour of breast cancer MCF7 cells
Conclusions Interfering the expression of Survivin can inhibit the cell proliferation, migration and invasion, and promot apoptosis in MCF–7.
Source: Asian Pacific Journal of Tropical Medicine - April 27, 2015 Category: Tropical Medicine Source Type: research

Changes of TIZ expression in epithelial ovarian cancer cells
Conclusions The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.
Source: Asian Pacific Journal of Tropical Medicine - April 27, 2015 Category: Tropical Medicine Source Type: research

Proteomics Profiling of Chikungunya-Infected Aedes albopictus C6/36 Cells Reveal Important Mosquito Cell Factors in Virus Replication
In this study, the CHIKV-infected C6/36 cells with differential cellular proteins expression were profiled using two-dimensional gel electrophoresis (2DE) coupled with the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). 2DE analysis on CHIKV-infected C6/36 cells has shown 23 mosquito cellular proteins that are differentially regulated, and which are involved diverse biological pathways, such as protein folding and metabolic processes. Among those identified mosquito proteins, spermatogenesis-associated factor, enolase phosphatase e-1 and chaperonin-60kD have been found to...
Source: PLoS Neglected Tropical Diseases - March 4, 2015 Category: Tropical Medicine Authors: Regina Ching Hua Lee et al. Source Type: research

Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7
Conclusions The targeted GPC3 siRNA can effectively inhibit the expression of GPC3.
Source: Asian Pacific Journal of Tropical Medicine - October 12, 2014 Category: Tropical Medicine Source Type: research

Effect of siRNA interference on nerve growth factor in intervertebral disc inflammation rats
Conclusions These molecular biological results suggest that inflammatory factor IL-6 and IL-1β could stimulate NGF on intervertebral disc cells in vitro culture model and its efficiency is concentration dependent, while siRNA interference can inhibit the stimulation effect of IL-6 and IL-1β on intervertebral disc cell, which provides a new targets for the clinical treatment of discogenic low back pain.
Source: Asian Pacific Journal of Tropical Medicine - October 12, 2014 Category: Tropical Medicine Source Type: research

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