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Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch, Madhuri S Salker Tags: Research Article Source Type: research

Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.
Abstract Phthalates are being suggested to be associated with altered thyroid function and proliferative changes, but detailed mechanisms remain unclear. Here, we examined the effects of di-(2-ethylhexyl) phthalate (DEHP) on DNA damage and proliferation in thyroid using thyroid carcinoma cell line, 8505C, in vitro and the rats orally treated with DEHP at 0, 0.3, 3, 30 and 150 mg/kg for 90 days from post-natal day 9 in vivo. Exposure to DHEP (1-50 μM) induced cellular proliferation, as evidenced by increased cell viability and DNA synthesis. Activation of γH2AX, a sensitive biomarker for DNA damage was observ...
Source: Food and Chemical Toxicology - December 10, 2018 Category: Food Science Authors: Kim S, Park GY, Yoo YJ, Jeong JS, Nam KT, Jee SH, Lim KM, Lee YS Tags: Food Chem Toxicol Source Type: research

Rubus idaeus L. Reverses Epithelial-to-Mesenchymal Transition and Suppresses Cell Invasion and Protease Activities by Targeting ERK1/2 and FAK Pathways in Human Lung Cancer Cells.
Abstract Epithelial to mesenchymal transition (EMT) has been considered essential for cancer metastasis, a multistep complicated process including local invasion, intravasation, extravasation, and proliferation at distant sites. Herein we provided molecular evidence associated with the antimetastatic effect of Rubus idaeus L. extracts (RIE) by showing a nearly complete inhibition on the invasion (p < 0.001) of highly metastatic A549 cells via reduced activities of matrix metalloproteinase-2 (MMP-2) and urokinasetype plasminogen activator (u-PA). We performed Western blot to find that RIE could induce up-regulat...
Source: Food and Chemical Toxicology - October 23, 2013 Category: Food Science Authors: Hsieh YS, Chu SC, Hsu LS, Chen KS, Lai MT, Yeh CH, Chen PN Tags: Food Chem Toxicol Source Type: research

Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress.
Abstract Prolonged endoplasmic reticulum (ER) stress may activate apoptotic pathways in cancer cells. It is suggested that ER stress has the potential of enhancing tumor death in cancer therapy. Galangin, a flavonol derived from Alpinia officinarum Hance, has been shown to suppress the proliferation of hepatocellular carcinoma cells (HCC). The aim of this study was to determine whether galangin was able to induce ER stress in HepG2, Hep3B and PLC/PRF/5 cells. The proliferation of HCC was tested by MTT method. Intracellular Ca(2+) levels were measured with Fluo3-AM.The proteins levels of GRP94, GRP78 and CHOP were ...
Source: Food and Chemical Toxicology - October 22, 2013 Category: Food Science Authors: Su L, Chen X, Wu J, Lin B, Zhang H, Lan L, Luo H Tags: Food Chem Toxicol Source Type: research