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Mistletoe (viscum album) extract targets Axl to suppress cell proliferation and overcome cisplatin- and erlotinib-resistance in non-small cell lung cancer cells.
Conclusion : Taken together, our data provide that VAE targets Axl to suppress cell proliferation and to circumvent cisplatin- and erlotinib-resistance in NSCLC cells. Graphical abstract
Source: Phytomedicine - September 29, 2017 Category: Drugs & Pharmacology Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Yaping Ye, Xingzhi Jing, Na Li, Yingxing Wu, Bingbing Li, Tao Xu Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regul...
Source: Biomedicine and Pharmacotherapy - January 21, 2017 Category: Drugs & Pharmacology Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.
Abstract Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regulation of rat adipose-derived stem cells (rASCs) proliferation and osteogenic differentiation. In the present study, we detected that icariin pro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 21, 2017 Category: Drugs & Pharmacology Authors: Ye Y, Jing X, Li N, Wu Y, Li B, Xu T Tags: Biomed Pharmacother Source Type: research

Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease.
CONCLUSIONS: We demonstrated RSV had anti-inflammatory effects on HCAECs via induction of autophagy. Our results suggest that resveratrol may modulate the inflammatory response of coronary artery in KD and explore the role of autophagy in the pathogenesis and alternative therapy of coronary arterial lesions in KD. PMID: 28069066 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - January 13, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research