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Specialty: Drugs & Pharmacology
Nutrition: High Fat
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Total 54 results found since Jan 2013.
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research
Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice
Biomed Pharmacother. 2022 Nov 13;157:114005. doi: 10.1016/j.biopha.2022.114005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common among lipid metabolism disorders. Autophagy plays an important role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active ingredients of Pueraria lobata, exert antioxidant and anti-inflammatory effects. Herein, we report the potential lipid-lowering and anti-inflammatory effects of Pueraria flavonoids on NAFLD induced by a high-fat diet. In vivo and in vitro experiments showed that Pueraria flavonoids reduced intracellular lipid deposition by...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 16, 2022 Category: Drugs & Pharmacology Authors: Chunbin Sun Jin Zhang Jiong Hou Menglin Hui Hualong Qi Tong Lei Xiaoshuang Zhang Luxi Zhao Hongwu Du Source Type: research
Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway
This study indicates that baicalin is able to attenuate hepatic cell pyroptosis in vivo and in vitro in the case of NASH by regulating the NRF2/HO-1/NRLP3 pathway.PMID:36184988 | DOI:10.1016/j.ejphar.2022.175270
Source: European Journal of Pharmacology - October 3, 2022 Category: Drugs & Pharmacology Authors: Huilian Shi Fei Qiao Weiting Lu Kaiyue Huang Yuanyuan Wen Lifang Ye Yuanyuan Chen Source Type: research
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research
Downregulation of peripheral lipopolysaccharide binding protein impacts on perigonadal adipose tissue only in female mice
CONCLUSION: LBP seems to exert a negative feedback on ERα-mediated estrogen action, impacting on genes involved in thermogenesis. The known decreased estrogen action and negative effects of metabolic endotoxemia may be targeted through LBP downregulation.PMID:35643066 | DOI:10.1016/j.biopha.2022.113156
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 1, 2022 Category: Drugs & Pharmacology Authors: Ferran Comas Ramon D íaz-Trelles Aleix Gavald à-Navarro Edward Milbank Nathalia Dragano Samantha Mor ón-Ros Rajesh Mukthavaram Jessica Latorre Francisco Ortega Maria Arnoriaga-Rodriguez N úria Oliveras-Cañellas Wifredo Ricart Priya P Karmali Kiyoshi Source Type: research
Adapalene induces adipose browning through the RAR β-p38 MAPK-ATF2 pathway
This study identifies new actions of AD as an adipose browning agent and demonstrates that RARβ activation followed by increased phosphorylation of p38 MAPK and ATF2 appears to be a key mechanism of AD action.PMID:35608792 | DOI:10.1007/s12272-022-01384-4
Source: Archives of Pharmacal Research - May 24, 2022 Category: Drugs & Pharmacology Authors: Na Hyun Lee Mi Jin Choi Hana Yu Jea Il Kim Hyae Gyeong Cheon Source Type: research
Hemin mitigates contrast-induced nephropathy by inhibiting ferroptosis via HO-1/Nrf2/GPX4 pathway
In this study, we aim to investigate the effect of hemin on CIN model and the underlying molecular mechanisms in human proximal tubule epithelial cells (HK-2) cells. To mimic a common condition in PCI patients, CIN was induced by intravenous iopromide in high-fat fed diabetic rats. We found hemin, given right before iopromide, mitigated CIN with enhanced antioxidative capacity and reduced oxidative stress. HK-2 cells insulted by iopromide demonstrated decreased cell vitality and rising ROS, which could also be inhibited by hemin. The effects of hemin involved a key molecule in ferroptosis, glutathione peroxidase (GPX4), wh...
Source: Clinical and Experimental Pharmacology and Physiology - May 22, 2022 Category: Drugs & Pharmacology Authors: Zhao Gao Ziyue Zhang Daqian Gu Yunqian Li Kun Zhang Xiaoli Dong Lingli Liu Jiye Zhang Jimin Chen Duozhi Wu Min Zeng Source Type: research
