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Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Pharmaceutical Biology - July 6, 2023 Category: Drugs & Pharmacology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research

Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells
This study is the first to demonstrate that curcumin can prevent oxidative stress-induced auditory hair cell degeneration through Nrf2 activation, highlighting its potential therapeutic value in preventing ARHL.PMID:37334787 | DOI:10.1016/j.bcp.2023.115575
Source: Biochemical Pharmacology - June 19, 2023 Category: Drugs & Pharmacology Authors: Ning Li Xirui Yan Weiling Huang Min Chu Yang Dong Haiyan Song Yinting Peng Jianrong Shi Qing Liu Source Type: research

Resveratrol attenuates hydrogen peroxide-induced injury of rat ovarian granulosa-lutein cells by resisting oxidative stress via the SIRT1/Nrf2/ARE signaling pathway
CONCLUSION: This study demonstrates that resveratrol attenuated oxidative stress to protect H2O2-induced rat ovarian granulosa-lutein cell injury and apoptosis via SIRT1/Nrf2/ARE signaling pathway.PMID:37013424 | DOI:10.2174/1381612829666230403133322
Source: Current Pharmaceutical Design - April 4, 2023 Category: Drugs & Pharmacology Authors: Minghui Cai Jiao Wang Haijuan Sun Qi Guo Chi Zhang Haixu Yao Chen Zhao Yuhan Jia Hui Zhu Source Type: research

Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research

Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK- α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
This study aimed to explore the protective roles of malvidin in life-threatened sepsis-associated encephalopathy (SAE) and illustrate the underlying mechanism. SAE mice models were developed and treated with malvidin for subsequently protective effects evaluation. Malvidin restored neurobehavioral retardation, declined serum S100β and NSE levels, sustained cerebrum morphological structure, improved blood-brain barrier integrity with elevated tight junction proteins, and decreased evans blue leakage, and finally protect SAE mice from brain injury. Mechanistically, malvidin prevented cerebrum from mitochondrial dysfunction ...
Source: Frontiers in Pharmacology - January 9, 2023 Category: Drugs & Pharmacology Source Type: research

Luteolin alleviated neutrophilic asthma by inhibiting IL-36 γ secretion-mediated MAPK pathways
CONCLUSIONS: Luteolin alleviated neutrophilic asthma by inhibiting IL-36γ secretion-mediated MAPK pathways. These findings provided a theoretical basis for the application of luteolin in the treatment of neutrophilic asthma.PMID:36604842 | DOI:10.1080/13880209.2022.2160770
Source: Pharmaceutical Biology - January 6, 2023 Category: Drugs & Pharmacology Authors: Xin-Rui Qiao Tao Feng Dong Zhang Li-Li Zhi Jin-Tao Zhang Xiao-Fei Liu Yun Pan Jia-Wei Xu Wen-Jing Cui Liang Dong Source Type: research

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