• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Use of Iontophoresis Technology for Transdermal Delivery of a Minimal mRNA Vaccine as a Potential Melanoma Therapeutic
Biol Pharm Bull. 2023;46(2):301-308. doi: 10.1248/bpb.b22-00746.ABSTRACTmRNA vaccines have attracted considerable attention as a result of the 2019 coronavirus pandemic; however, challenges remain regarding use of mRNA vaccines, including insufficient delivery owing to the high molecular weights and high negative charges associated with mRNA. These characteristics of mRNA vaccines impair intracellular uptake and subsequent protein translation. In the current study, we prepared a minimal mRNA vaccine encoding a tumor associated antigen human gp10025-33 peptide (KVPRNQDWL), as a potential treatment for melanoma. Minimal mRNA...
Source: Biological and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rabab A Husseini Naoko Abe Tomoaki Hara Hiroshi Abe Kentaro Kogure Source Type: research

Directing the Way —Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery
AbstractNucleic acid therapeutics have shown great potential for the treatment of numerous diseases, such as genetic disorders, cancer and infections. Moreover, they have been successfully used as vaccines during the COVID-19 pandemic. In order to unfold full therapeutical potential, these nano agents have to overcome several barriers. Therefore, directed transport to specific tissues and cell types remains a central challenge to receive carrier systems with enhanced efficiency and desired biodistribution profiles. Active targeting strategies include receptor-targeting, mediating cellular uptake based on ligand-receptor in...
Source: Pharmaceutical Research - September 15, 2022 Category: Drugs & Pharmacology Source Type: research

Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether ‐à‐go‐go–Related Gene and Cav1.2
Conclusion: Chronic incubation with FLV and LPV produced more severe channel-blocking effects and contributed to altered channel gating and shortened action potential duration by inhibiting hERG and Cav1.2.
Source: Frontiers in Pharmacology - July 7, 2022 Category: Drugs & Pharmacology Source Type: research

Drug repurposing of dextromethorphan as a cellular target for the management of influenza
ConclusionInfluenza viruses continue to emerge and cause infection (including pandemics) in humans, so there remains a critical need to advance the understanding of influenza treatment. Our results demonstrated reduced hospitalization rates for influenza patients treated with DM. Further research on cellular targets and / or DM are warranted for the treatment of influenza.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 24, 2021 Category: Drugs & Pharmacology Authors: Tammy H. Cummings, Joseph Magagnoli, James W. Hardin, S. Scott Sutton Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Pages: 1  2