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Total 140 results found since Jan 2013.
Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells
This study is the first to demonstrate that curcumin can prevent oxidative stress-induced auditory hair cell degeneration through Nrf2 activation, highlighting its potential therapeutic value in preventing ARHL.PMID:37334787 | DOI:10.1016/j.bcp.2023.115575
Source: Biochemical Pharmacology - June 19, 2023 Category: Drugs & Pharmacology Authors: Ning Li Xirui Yan Weiling Huang Min Chu Yang Dong Haiyan Song Yinting Peng Jianrong Shi Qing Liu Source Type: research
TAX1BP1 contributes to deoxypodophyllotoxin-induced glioma cell parthanatos via inducing nuclear translocation of AIF by activation of mitochondrial respiratory chain complex I
In this study we explored the downstream signal of activated PARP1 to induce nuclear translocation of AIF in DPT-triggered glioma cell parthanatos. We showed that treatment with DPT (450 nM) induced PARP1 over-activation and Tax1 binding protein 1 (TAX1BP1) distribution to mitochondria in human U87, U251 and U118 glioma cells. PARP1 activation promoted TAX1BP1 distribution to mitochondria by depleting nicotinamide adenine dinucleotide (NAD+). Knockdown of TAX1BP1 with siRNA not only inhibited TAX1BP1 accumulation in mitochondria, but also alleviated nuclear translocation of AIF and glioma cell death. We demonstrated that T...
Source: Acta Pharmacologica Sinica - May 15, 2023 Category: Drugs & Pharmacology Authors: Xuan-Zhong Wang Shi-Peng Liang Xi Chen Zhen-Chuan Wang Chen Li Chun-Sheng Feng Shan Lu Chuan He Yu-Bo Wang Guang-Fan Chi Peng-Fei Ge Source Type: research
Cell surface GRP78 regulates TGF β1-mediated profibrotic responses via TSP1 in diabetic kidney disease
Discussion: These data support an important role for csGRP78 in regulating HG-induced TSP1 transcriptional induction via PI3K/Akt signaling. Functionally, this enables TGFβ1 activation in response to HG, with consequent increase in ECM proteins. Means of inhibiting csGRP78 signaling represent a novel approach to preventing fibrosis in DKD.
Source: Frontiers in Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research
MiR-133a-3p/Sirt1 epigenetic programming mediates hypercholesterolemia susceptibility in female offspring induced by prenatal dexamethasone exposure
In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats.PMID:36326533 | DOI:10.1016/j.bcp.2022.115306
Source: Biochemical Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Authors: Xufeng Li Wen Hu Li Li Ze Chen Tao Jiang Dingmei Zhang Kexin Liu Hui Wang Source Type: research
Pyrroloquinoline quinone modulates YAP-related anti-ferroptotic activity to protect against myocardial hypertrophy
Conclusion: PQQ can regulate the pathogenesis of myocardial hypertrophy through the induction of YAP-related anti-ferroptotic activity, highlighting the potential value of PQQ as a novel therapeutic agent capable of slowing or preventing the progression of myocardial hypertrophy and thus delaying the onset of heart failure.
Source: Frontiers in Pharmacology - September 27, 2022 Category: Drugs & Pharmacology Source Type: research
Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease
Biomed Pharmacother. 2022 Jun 7;152:113244. doi: 10.1016/j.biopha.2022.113244. Online ahead of print.ABSTRACTAirway mucus hypersecretion is a vital pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients in which airflow limitation result, and it is key to strategizing in the management of COPD. To investigate the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated, human organoid model of trachea was established and all trea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2022 Category: Drugs & Pharmacology Authors: Yuan-Yuan Wei Da-Wei Zhang Jing-Jing Ye Qing-Xia Lan Shuang Ji Li Sun Fang Li Guang-He Fei Source Type: research
Combinational Silencing of Components Involved in JAK/STAT Signaling Pathway
In conclusion, the promising results of simultaneous targeting of JAK2 and gp 130 might be an example for potential combinatorial silencing strategies in cancer treatment.PMID:35680032 | DOI:10.1016/j.ejps.2022.106233
Source: European Journal of Pharmaceutical Sciences - June 9, 2022 Category: Drugs & Pharmacology Authors: Emira Bousoik Parvin Mahdipoor Abdulelah Alhazza Hamidreza Montazeri Aliabadi Source Type: research
Endoplasmic reticulum stress induces degradation of glucose transporter proteins during hyperglycemic hepatotoxicity: Role of PERK-eIF2 α-ATF4 axis
Eur J Pharmacol. 2022 May 11:175012. doi: 10.1016/j.ejphar.2022.175012. Online ahead of print.ABSTRACTHyperglycemia induced reactive oxygen species oxidize macromolecules including cellular proteins leading to their accumulation in Endoplasmic Reticulum (ER) lumen which in turn activates unfolded protein response (UPR) sensors including, PERK (Protein Kinase RNA-Like ER Kinase). Activated PERK induces ER associated degradation of misfolded proteins to lower the ER stress. In the present study, we hypothesized that ER stress leads to the degradation of glucose transporter proteins resulting in complex glucose metabolism. In...
Source: European Journal of Pharmacology - May 14, 2022 Category: Drugs & Pharmacology Authors: Vivek Kumar Pandey Alpana Mathur Mohammad Fareed Khan Poonam Kakkar Source Type: research
