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Specialty: Drugs & Pharmacology
Cancer: Liver Cancer

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Total 82 results found since Jan 2013.

Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy
Autophagy related gene 101 (ATG101) plays a significant role in the occurrence and development of tumours by responding to stress. Our research aims to illustrate the correlation between the expression of ATG101 and tumor prognosis and its potential role and mechanism in tumor immunity and photodynamic therapy (PDT). First, integrated analysis of The Cancer Genome Atlas and Genotype-Tissue Expression portals were used to analyse the expression of ATG101. Then, Kaplan–Meier curves was applied in cholangiocarcinoma (CHOL) and liver hepatocellular carcinoma (LIHC) datasets for survival analysis. Next, the relationship betwe...
Source: Frontiers in Pharmacology - May 3, 2022 Category: Drugs & Pharmacology Source Type: research

Inhibitory Effect of Aptamer-Carbon Dot Nanomaterial-siRNA Complex on the Metastasis of Hepatocellular Carcinoma Cells by Interfering with FMRP
Eur J Pharm Biopharm. 2022 Mar 29:S0939-6411(22)00061-3. doi: 10.1016/j.ejpb.2022.03.013. Online ahead of print.ABSTRACTUsing small interfering RNA (siRNA) for the specific gene-silencing has been a novel therapeutic method for the treatment of incurable diseases such as malignancies. However, it remains a challenge whether siRNA can be safely and effectively delivered into target cells. Therefore, we synthesized fluorescent carbon dots (CDs) as a gene vector at the siRNA delivery system that induced efficient gene knockdown in vitro while binding aptamer AS1411 to resolve the difficulty in cell targeting. We found that CD...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 1, 2022 Category: Drugs & Pharmacology Authors: Xiaoliang Zhao Jie Yang Jing Zhang Xiangyun Wang Lulu Chen Chao Zhang Zhifa Shen Source Type: research

Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma
Biochem Pharmacol. 2021 Oct 18;193:114806. doi: 10.1016/j.bcp.2021.114806. Online ahead of print.ABSTRACTThe pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes with diagnostic and prognostic meaning and to identify potential therapeutic agents for HCC treatment. Here, CDK1, CCNB1 and CCNB2 were found to be highly expressed in HCC patients and accompanied by poor prognosis, and knockdown of them by siRNA drastically induced autophagy...
Source: Biochemical Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Authors: Shuangshuang Yin Shenshen Yang Yanming Luo Jia Lu Gaoyong Hu Kailong Wang Yingying Shao Shiyue Zhou Sangho Koo Yuling Qiu Tao Wang Haiyang Yu Source Type: research

NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma
In this study, we detected the upregulated expression of NAP1L1 mRNA and protein levels by quantitative polymerase chain reaction and Western blot analysis in NPC cell lines. Results of the immunohistochemistry analysis of NPC tissue biopsies showed that upregulated NAP1L1 protein expression promoted NPC progression and negatively correlated with poor prognosis in NPC patients. Suppression of NAP1L1 expression by small interfering RNA (siRNA) or small hairpin RNA (shRNA) methods significantly decreased cell proliferation in vivo and in vitro. Mechanism analysis revealed that the regulation of cell growth was enriched by Ge...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 26, 2021 Category: Drugs & Pharmacology Authors: YaHui Liu XiaoNing Li YeWei Zhang Yao Tang WeiYi Fang Xiong Liu Zhen Liu Source Type: research

SMG9 Serves as an Oncogene to Promote the Tumor Progression via EMT and Wnt/ β-Catenin Signaling Pathway in Hepatocellular Carcinoma
Conclusions: SMG9 may serve as a potential novel prognostic biomarker and therapeutic target in HCC patients.
Source: Frontiers in Pharmacology - August 12, 2021 Category: Drugs & Pharmacology Source Type: research

Advantages and Challenges in nanomedicines for chronic liver diseases: a hepatologist's perspectives.
Abstract Chronic liver disease (CLD) is responsible for significant morbidity and mortality worldwide. CLD patients are at a high risk of developing progressive liver fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and subsequent liver failure. To date, there is no specific and effective therapies exist for patients with various forms of CLD. The application of nanotechnology has emerged as a rapidly developing area of interest for the safe and target-specific delivery of poorly aqueous soluble hepatoprotective agents and nucleic acids (siRNA/miRNAs) in CLD. The nanoparticle combination improves bioavailabili...
Source: European Journal of Pharmacology - December 21, 2020 Category: Drugs & Pharmacology Authors: Ezhilarasan D Tags: Eur J Pharmacol Source Type: research

Circular RNA ZNF292 affects proliferation and apoptosis of hepatocellular carcinoma cells by regulating Wnt/ β-catenin pathway.
CONCLUSIONS: Knock downing circRNA ZNF292 leads to cell cycle arrest in G1 phase, thus suppressing cell proliferation and promoting cell apoptosis. The regulatory mechanism of circRNA ZNF292 may involve the regulation of cell cycle and related genes. PMID: 33336730 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 19, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice
Conclusion: Our data uncover a novel mechanism for hepatoprotective effects of Sal A against lipotoxicity both in livers from HFCD-fed mice and palmitic acid-treated hepatocytes.
Source: Frontiers in Pharmacology - November 30, 2020 Category: Drugs & Pharmacology Source Type: research

Significance of TRPS1 in the development and clinicopathologic of hepatocellular carcinoma.
CONCLUSIONS: TRPS1 plays a key role in the development of HCC and is closely associated with the clinicopathological parameters of HCC patients. Hence, it is proposed that TRPS1 may serve as a novel prognostic marker and a potential therapeutic target for HCC treatment. PMID: 33015773 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 7, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research