• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Rubicon promotes the M2 polarization of Kupffer cells via LC3-associated phagocytosis-mediated clearance to improve liver transplantation
CONCLUSIONS: Rubicon-mediated LAP promotes the clearance capability and M2 polarization of KCs via PUFA-dependent PPARγ activation to improve LT.PMID:35700602 | DOI:10.1016/j.cellimm.2022.104556
Source: Cellular Immunology - June 14, 2022 Category: Allergy & Immunology Authors: Yajun Chen Yiping He Xinyi Wu Xuesong Xu Junhua Gong Yong Chen Jianping Gong Source Type: research

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

NF κB and Kidney Injury
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Inhibition of Interferon Regulatory Factor 4 Attenuates Acute Liver Allograft Rejection in Mice
In conclusion, inhibition of IRF4 attenuates acute liver allograft rejection in mice, and this is associated with promoted M2 macrophage differentiation. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - June 12, 2015 Category: Allergy & Immunology Authors: Wei Zhao, Zhong Zhang, Qingjun Zhao, Mengjie Liu, Yuelan Wang Tags: Regular Article Source Type: research

Platelet Factor 4 Limits Th17 Differentiation and Ischaemia–Reperfusion Injury After Liver Transplantation in Mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via upregulation of SOCS3.
Source: Scandinavian Journal of Immunology - January 20, 2015 Category: Allergy & Immunology Authors: H. Guo, Y. Wang, Z. Zhao, X. Shao Tags: Experimental Immunology Source Type: research

Platelet factor 4 limits Th17 differentiation and ischemia‐reperfusion injury after liver transplantation in mice
In conclusion, PF4 limits liver IRI through IL‐17 inhibition via up‐regulation of SOCS3. This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - November 29, 2014 Category: Allergy & Immunology Authors: Hefeng Guo, Zhiming Zhao, Yue Wang Tags: Regular Manuscript Source Type: research