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Review of Current Machine Perfusion Therapeutics for Organ Preservation
Because of the high demand of organs, the usage of marginal grafts has increased. These marginal organs have a higher risk of developing ischemia-reperfusion injury, which can lead to posttransplant complications. Ex situ machine perfusion (MP), compared with the traditional static cold storage, may better protect these organs from ischemia-reperfusion injury. In addition, MP can also act as a platform for dynamic administration of pharmacological agents or gene therapy to further improve transplant outcomes. Numerous therapeutic agents have been studied under both hypothermic (1–8°C) and normothermic settings. Here, we...
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

δV1‐1 Reduces Pulmonary Ischemia Reperfusion‐Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of PKCδ and p53
Ischemia–reperfusion (IR)‐induced lung injury is one of the major contributing factors of morbidity and mortality after lung transplantation. To determine the IR‐induced molecular changes in lung epithelial cells, we developed a cell‐culture model that simulates lung preservation and transplantation. Six hours of cold ischemic time (CIT) and reperfusion elicited production of multiple inflammatory cytokines and chemokines and increased expression of endoplasmic reticulum (ER) proteins. Prolonged hypothermic condition (18 h CIT) reduced ER stress protein levels, and induced apoptosis and necrosis (via mechanisms rel...
Source: American Journal of Transplantation - September 14, 2015 Category: Transplant Surgery Authors: H. Kim, J. Zhao, Q. Zhang, Y. Wang, D. Lee, X. Bai, L. Turrell, M. Chen, W. Gao, S. Keshavjee, M. Liu Tags: Original Article Source Type: research

MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure
Conclusions: MicroRNA-150 counteracts ADIPOR2 up-regulation in CHF and thus may contribute to adiponectin resistance. Targeting microRNA-150 may be a future strategy to restore cardioprotective adiponectin effects.
Source: The Journal of Heart and Lung Transplantation - October 28, 2013 Category: Transplant Surgery Authors: Simone Kreth, Carola Ledderose, Stefanie Schütz, Andres Beiras, Jens Heyn, Florian Weis, Andres Beiras-Fernandez Tags: Featured Articles Source Type: research

MAPK mediates inflammatory response and cell death in rat pulmonary microvascular endothelial cells in an ischemia–reperfusion model of lung transplantation
Conclusions: Exposing rat PMVECs to simulated non-hypoxic IR caused lipid peroxidation, inflammation and apoptosis, which required MAPK-mediated NF-κB and AP-1 activation and distinct regulation of MAPKs by these 2 transcription factors. This model could be used to uncouple mechanisms of IR and evaluate potential therapeutics in alleviating IR injury.
Source: The Journal of Heart and Lung Transplantation - June 10, 2013 Category: Transplant Surgery Authors: Jing Tan, Dongdong Liu, Xiangqi Lv, Linlin Wang, Can Zhao, Yuxiang Che, Qing Xie, Xiaoguang Cui Tags: Original Pre-clinical Science Source Type: research