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Procedure: Induction of Labor

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Total 32 results found since Jan 2013.

NRF2 protects against ROS-induced preterm premature rupture of membranes through regulation of mitochondria †
Biol Reprod. 2023 Jul 10:ioad075. doi: 10.1093/biolre/ioad075. Online ahead of print.ABSTRACTPreterm premature rupture of membranes (pPROM) is a major cause of preterm birth and neonatal mortality. Reactive oxygen species (ROS) have been identified as a critical factor in the development of pPROM. Mitochondria are known to be the primary source of ROS and play a vital role in maintaining cellular function. The Nuclear erythroid 2-related factor 2 (NRF2) has been demonstrated to play a crucial role in regulating mitochondrial function. However, research exploring the impact of NRF2-regulated mitochondria on pPROM is limited...
Source: Reproductive Biology - July 10, 2023 Category: Reproduction Medicine Authors: Xinyuan Zhang Xiao He Linna Wei Yang He Yunlong Li Yingxiong Wang Chunli Li Source Type: research

GIT2 deficiency attenuates inflammation induced expression of pro-labor mediators in human amnion and myometrial cells.
Abstract Untimely activation of the inflammatory response by sterile or infective insults in uterine tissues can result in preterm birth. Pro-inflammatory cytokines and pathogenic activation of toll-like receptors (TLRs) initiates a biochemical cascade of events leading to myometrial activation and contractility, cervical dilatation, and rupture of the chorioamniotic membranes. GIT2 is a signaling protein known to play a role in innate and adaptive immunity; however, its role in the inflammatory pathways of human labor are not known. In this article, we report that GIT2 expression is lower in human myometrium and ...
Source: Reproductive Biology - March 26, 2019 Category: Reproduction Medicine Authors: Lim R, Lappas M Tags: Biol Reprod Source Type: research

IRF5 is increased in labouring myometrium and regulates pro-labour mediators
Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatment options stem from our incomplete understanding of the mechanisms of human labour and delivery. Activation of the inflammatory response in gestational tissues by inflammation and/or infection leads to the production of pro-inflammatory and pro-labour mediators, thus preterm birth. Interferon regulatory factor 5 (IRF5) has recently emerged as an important pro-inflammatory transcription factor involved in acute and chronic inflammation. The aims of this study were to determine the expression of ...
Source: Reproduction - August 17, 2018 Category: Reproduction Medicine Authors: Lim, R., Barker, G., Lappas, M. Tags: Research Source Type: research

The immunoproteasome inhibitor ONX-0914 regulates inflammation and expression of contraction associated proteins in myometrium.
This article is protected by copyright. All rights reserved. PMID: 29883518 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - June 8, 2018 Category: Allergy & Immunology Authors: Liong S, Lim R, Nguyen-Ngo C, Barker G, Parkington HC, Lappas M Tags: Eur J Immunol Source Type: research

DREAM Is Involved in the Genesis of Inflammation-Induced Prolabour Mediators in Human Myometrial and Amnion Cells.
Abstract Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor-κB (NF-κB). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF-κB activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells. DREAM mRNA expression was significantly higher in fetal membranes obtained after spontaneou...
Source: Biomed Res - April 24, 2018 Category: Research Authors: Goradia P, Lim R, Lappas M Tags: Biomed Res Int Source Type: research

NOD ‐like receptor pyrin domain‐containing‐3 (NLRP3) regulates inflammation‐induced pro‐labor mediators in human myometrial cells
ConclusionNLRP3 is increased with labor in myometrial, and knockdown of NLRP3 is associated with an attenuation of inflammation‐induced expression of pro‐inflammatory and pro‐labor mediators in human myometrium.
Source: American Journal of Reproductive Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Ratana Lim, Martha Lappas Tags: ORIGINAL ARTICLE Source Type: research

PARK7 regulates inflammation-induced pro-labour mediators in myometrial and amnion cells
Preterm birth is a prevalent cause of neonatal deaths worldwide. Inflammation has been implicated in spontaneous preterm birth involved in the processes of uterine contractility and membrane rupture. Parkinson protein 7 (PARK7) has been found to play an inflammatory role in non-gestational tissues. The aims of this study were to determine the expression of PARK7 in myometrium and fetal membranes with respect to term labour onset and to elucidate the effect of PARK7 silencing in primary myometrium and amnion cells on pro-inflammatory and pro-labour mediators. PARK7 mRNA expression was higher in term myometrium and fetal mem...
Source: Reproduction - January 22, 2018 Category: Reproduction Medicine Authors: Lim, R., Barker, G., Lappas, M. Tags: Research Source Type: research

The IL-1 β signalling pathway and its role in regulating pro-inflammatory and pro-labour mediators in human primary myometrial cells.
This study sought to determine the role of the adaptor proteins myeloid differentiation primary response 88 (MyD88), tumour necrosis factor receptor-associated factor 6 (TRAF6), IL-1 receptor-associated kinase 4 (IRAK4) and transforming growth factor beta-activated kinase 1 (TAK1) in IL-1β-induced formation of pro-inflammatory and pro-labour mediators in human myometrium. Human primary myometrial cells were transfected with siRNA against MyD88 (siMYD88), TRAF6 (siTRAF6), IRAK4 (siIRAK4) or TAK1 (siTAK1), treated with IL-1β, and assayed for the mRNA expression and or secretion of pro-inflammatory and pro-labour mediators....
Source: Reproductive Biology - October 6, 2017 Category: Reproduction Medicine Authors: Lappas M Tags: Reprod Biol Source Type: research