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Specialty: Molecular Biology
Procedure: Transplants
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Total 39 results found since Jan 2013.
Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines
CONCLUSIONS: Our results showed for the first time that silencing TOLLIP in hepatocellular carcinoma cells may help sensitize these cells to doxorubicin and increase the efficacy of chemotherapeutic regimens where doxorubicin is used.PMID:37644370 | DOI:10.1007/s11033-023-08737-2
Source: Mol Biol Cell - August 29, 2023 Category: Molecular Biology Authors: Ayse Banu Demir Elif Baris Umay Bengi Kaner Hani Alotaibi Nese Atabey Ahmet Koc Source Type: research
Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma
Matrix Biol. 2022 Nov 11:S0945-053X(22)00134-2. doi: 10.1016/j.matbio.2022.11.002. Online ahead of print.ABSTRACTSeveral collagen subtypes are involved in pancreatic ductal adenocarcinoma (PDAC) desmoplasia, which constrains therapeutic efficacy. We evaluated collagen type VIII alpha 1 chain (COL8A1), whose function in PDAC is currently unknown. We identified COL8A1 expression in 7 examined PDAC cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher COL8A1 expression occurred in 2 gemcitabine-resistant PDAC cell lines; pancreas tissue (n=15) from LSL-KrasG12D/+; Pdx-1-Cre mice with advanced PDAC predisp...
Source: Matrix Biology - November 14, 2022 Category: Molecular Biology Authors: Bin Yan Li Liu Lian Zhao Ulf Hinz Yiqiao Luo Xuefeng An Jury Gladkich Carolina de la Torre Zhenhua Huang Daniel Schrapel Wolfgang Gross Franco Fortunato Michael Sch äfer Matthias M Gaida Ingrid Herr Source Type: research
Bortezomib alleviates antibody-mediated rejection in kidney transplantation by facilitating Atg5 expression
J Cell Mol Med. 2021 Nov 3. doi: 10.1111/jcmm.16998. Online ahead of print.ABSTRACTAntibody-mediated rejection (AMR) is one of the most dominant mechanisms responsible for the loss of kidney grafts. Previous researches have shown that donor-specific antibodies (DSAs) are the major mediators of AMR. In order to prolong the survival time of grafts, it is vital to reduce the incidence of AMR and inhibit the generation of DSAs. We established an animal model of AMR by performing kidney transplantation in pre-sensitized rats. Then, we investigated the effect of bortezomib (BTZ) on AMR. We found that BTZ could reduce the serum l...
Source: J Cell Mol Med - November 4, 2021 Category: Molecular Biology Authors: Hong Cheng Bin Xu Lijie Zhang Yi Wang Ming Chen Shuqiu Chen Source Type: research
Ultrasound ‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats.
In conclusion, the present study demonstrated that UTMD‑mediated Galectin‑7‑siRNA treatment could enhance the homing ability of BMSCs, thus alleviating AMI in rats.
PMID: 33416139 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - December 23, 2020 Category: Molecular Biology Authors: Wei X, Zheng Y, Zhang W, Tan J, Zheng H Tags: Int J Mol Med Source Type: research
