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Total 33 results found since Jan 2013.
Extracellular Vesicles and Ischemic Cardiovascular Diseases
Adv Exp Med Biol. 2023;1418:57-68. doi: 10.1007/978-981-99-1443-2_4.ABSTRACTCharacterized by coronary artery obstruction or stenosis, ischemic cardiovascular diseases as advanced stages of coronary heart diseases commonly lead to left ventricular aneurysm, ventricular septal defect, and mitral insufficiency. Extracellular vesicles (EVs) secreted by diverse cells in the body exert roles in cell-cell interactions and intrinsic cellular regulations. With a lipid double-layer membrane and biological components such as DNA, protein, mRNA, microRNAs (miRNA), and siRNA inside, the EVs function as paracrine signaling for the patho...
Source: Advances in Experimental Medicine and Biology - August 21, 2023 Category: Research Authors: Yujiao Zhu Siqi Wang Xuerui Chen Source Type: research
LAP+CD4+T cells regulate the anti-tumor role of CIK cells in colorectal cancer through IL-10 and TGF- β
Am J Transl Res. 2022 Jun 15;14(6):3716-3728. eCollection 2022.ABSTRACTThe rate of colorectal cancer (CRC) is increasing. Adoptive immune cell therapy (ACT) is a research hotspot in CRC treatment, and the common adoptive cells are cytokine-induced killer cells (CIK). The problem of ACT is that some regulatory T cells (Treg) will affect the efficacy. Latent associated polypeptide (LAP)+CD4+T is a new Treg, and its immunosuppressive effect is much higher than that of traditional Tregs. This research mainly explored the influence of LAP+CD4+T cells on anti-tumor lethality of CIK cells, so as to fill this gap. The LAP+CD4+T CI...
Source: American Journal of Translational Research - July 15, 2022 Category: Research Authors: Wu Zhong Chuanfa Fang Hongquan Liu Lei Zhang Xiaofei Zhang Junqiao Zhong Xianping He Leichang Zhang Source Type: research
