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Normothermic Preservation of Liver - What Does the Future Hold?
Authors: Bral M, Shapiro AMJ Abstract Recent years have demonstrated a surging interest in normothermic ex situ liver perfusion, with iterative experimental and clinical studies establishing this technology as providing obvious advantages over static cold storage. In particular, the safe prolongation of liver graft preservation even up to 1 week opens up possibilities of 'on circuit' interventions, which may radically change the logistics and scope of liver transplant practice. Such approaches are rife with potential, and have yet to be fully explored. Possibilities may include, but are not limited to mitochondria...
Source: Advances in Experimental Medicine and Biology - April 15, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Knockout of density-enhanced phosphatase-1 impairs cerebrovascular reserve capacity in an arteriogenesis model in mice.
Abstract Collateral growth, arteriogenesis, represents a proliferative mechanism involving endothelial cells, smooth muscle cells, and monocytes/macrophages. Here we investigated the role of Density-Enhanced Phosphatase-1 (DEP-1) in arteriogenesis in vivo, a protein-tyrosine-phosphatase that has controversially been discussed with regard to vascular cell biology. Wild-type C57BL/6 mice subjected to permanent left common carotid artery occlusion (CCAO) developed a significant diameter increase in distinct arteries of the circle of Willis, especially in the anterior cerebral artery. Analyzing the impact of loss of D...
Source: Biomed Res - September 18, 2013 Category: Research Authors: Hackbusch D, Dülsner A, Gatzke N, Krüger J, Hillmeister P, Nagorka S, Blaschke F, Ritter Z, Thöne-Reineke C, Böhmer FD, Buschmann I, Kappert K Tags: Biomed Res Int Source Type: research