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Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells
CONCLUSIONS: Release of VWF from endothelial cells opens the platelet-binding site, irrespective of the presence of flow. However, not all available platelet-binding sites are being occupied, suggesting some extent of regulation. Part of this regulation involves endothelial proteins that are co-secreted with VWF, like osteoprotegerin. This regulatory mechanism may be of more relevance under inflammatory conditions.PMID:34816579 | DOI:10.1111/jth.15598
Source: Thrombosis and Haemostasis - November 24, 2021 Category: Hematology Authors: Nikolett Wohner Silvie Sebastian Vincent Muczynski Dana Huskens Bas de Laat Philip G de Groot Peter J Lenting Source Type: research

MiR-15b-5p Regulates Collateral Artery Formation by Targeting AKT3 (Protein Kinase B-3).
CONCLUSIONS: These results indicate that circulating miR-15b-5p is a suitable biomarker for discriminating between patients with well-developed or poorly developed collaterals. Moreover, miR-15b-5p is a key regulator of arteriogenesis and angiogenesis, which may represent a potential therapeutic target for ischemic disease. PMID: 28254819 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 1, 2017 Category: Cardiology Authors: Zhu LP, Zhou JP, Zhang JX, Wang JY, Wang ZY, Pan M, Li LF, Li CC, Wang KK, Bai YP, Zhang GG Tags: Arterioscler Thromb Vasc Biol Source Type: research