• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Metformin Promotes 2-Deoxy-2- 18 FFluoro-D-Glucose Uptake in Hepatocellular Carcinoma Cells Through FoxO1-Mediated Downregulation of Glucose-6-Phosphatase
ConclusionsWe propose that treatment of HCC cells with Met may be a useful strategy for improving the efficacy of [18F]FDG as a tracer for PET/CT imaging of HCC tumors in patients.
Source: Molecular Imaging and Biology - December 18, 2017 Category: Molecular Biology Source Type: research

Regulation of Acetate Utilization By Monocarboxylate Transporter 1 (MCT1) in Hepatocellular Carcinoma (HCC).
Authors: Jeon J, Lee M, Whang S, Kim JW, Cho A, Yun M Abstract Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular carcinoma (HCC) shows reciprocal18F-Fluorodeoxyglucose (FDG) and 11C-acetate uptake, as revealed by positron emission tomography/computed tomography (PET/CT). Previous studies have focused on the role of FDG uptake in cancer cells; in this study, we evaluated the mechanism and roles of 11C-acetate uptake in human HCCs and cell lines. The expression of monocarboxylate transporters (MCTs) was assessed to determine the transporters of 11C-acetate uptake in HCC cell lines...
Source: Oncology Research - April 9, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

The role of monocarboxylate transpoter 1 to uptake acetate in low glycolytic hepatocellular carcinoma cell line HepG2 cells
Conclusions Our data demonstrate that acetate was supported to HCC cells through MCT1 specifically in the low glycolytic cancer cells, and high MCT1 expression is related with low glycolytic phenotype cancer that would be the therapeutic target or diagnosis probe for low glycolytic cancers.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., kim, j., Yun, M. Tags: MTA I: Basic Science Posters Source Type: research

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice
Conclusions: EMF-guided 131I-hVEGF siRNA/SilenceMag exhibited an antitumor effect. The synergic therapy of 131I-hVEGF siRNA/SilenceMag might be a promising future treatment option against HCC with the dual functional properties of tumor therapy and imaging.
Source: BMC Cancer - February 21, 2014 Category: Cancer & Oncology Authors: Jing ChenShu ZhuLiangqian TongJiansha LiFei ChenYunfeng HanMing ZhaoWei Xiong Source Type: research