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PKC{alpha} regulates TMEM16A-mediated Cl- secretion in human biliary cells
In conclusion, our studies demonstrate that PKCα is coupled to ATP-stimulated TMEM16A activation in BECs. Targeting this ATP-Ca2+-PKCα signaling pathway may represent a therapeutic strategy to increase biliary secretion and promote bile formation.
Source: AJP: Gastrointestinal and Liver Physiology - January 1, 2016 Category: Gastroenterology Authors: Dutta, A. K., Khimji, A.-K., Liu, S., Karamysheva, Z., Fujita, A., Kresge, C., Rockey, D. C., Feranchak, A. P. Tags: LIVER AND BILIARY TRACT PHYSIOLOGY/PATHOPHYSIOLOGY Source Type: research

PKCα regulates TMEM16A-mediated Cl- secretion in human biliary cells.
In conclusion, our studies demonstrate that PKCα is coupled to ATP-stimulated TMEM16A activation in BECs. Targeting this ATP-Ca(2+)-PKCα signaling pathway may represent a therapeutic strategy to increase biliary secretion and promote bile formation. PMID: 26542395 [PubMed - as supplied by publisher]
Source: Am J Physiol Gastroi... - November 5, 2015 Category: Gastroenterology Authors: Dutta AK, Khimji AK, Liu S, Karamysheva Z, Fujita A, Kresge C, Rockey DC, Feranchak AP Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Cell signalling
Conclusions: Taken together, it is likely that klotho protects against renal fibrotic process accompanied by down-regulation of fibrotic markers, counteracting to TGF-β, and one of possible mechanism mediating translocation of Na/K ATPase, resulting in Ca+ channel stabilization/alternation of Ca+ ion concentration. Klotho should be involved in the accentuation of the progression of renal fibrosis in CKD.
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Tsuchiya, K., Shiohira, S., Sugiura, H., Suzuki, M., Okano, K., Nitta, K., Kaesler, N., Immendorf, S., Ouyang, C., Carmeliet, P., Floege, J., Kruger, T., Schlieper, G., Georgescu, A., Kalucka, J., Olbrich, S., Baumgartl, J., Hackenbeck, T., Eckardt, K.-U. Tags: Abstracts Source Type: research