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Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury
In conclusion, our study reveals that SIRT1/FXR pathway is crucial in OA-induced hepatotoxicity. Activation of SIRT1/HNF1α/FXR axis may represent a novel therapeutic target for ameliorating OA and other herb-induced hepatotoxicity.PMID:37028458 | DOI:10.1016/j.taap.2023.116509
Source: Toxicology and Applied Pharmacology - April 7, 2023 Category: Toxicology Authors: Songjie Liao Xiaolong Fu Jianxiang Huang Yi Wang Yuanfu Lu Shaoyu Zhou Source Type: research

Ephedrine-induced mitophagy via oxidative stress in human hepatic stellate cells.
In this study, we investigated hepatotoxicity and key regulation of mitophagy in ephedrine-treated LX-2 cells. Ephedrine triggered mitochondrial oxidative stress and depolarization. Mitochondrial swelling and autolysosome were observed in ephedrine-treated cells. Ephedrine also inhibited mitochondrial biogenesis, and the mitochondrial copy number was decreased. Parkin siRNA recovered the ephedrine-induced mitochondrial damage. Excessive mitophagy lead to cell death through imbalance of autophagic flux. Moreover, antioxidants and reducing Parkin level could serve as therapeutic targets for ephedrine-induced hepatotoxicity. ...
Source: Journal of Toxicological Sciences - July 21, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes.
In conclusion, the current results suggest that activation of SIRT3 substantially ameliorates the detrimental effects of TP by closing the mPTP. PMID: 27064125 [PubMed - as supplied by publisher]
Source: Toxicology in Vitro - April 6, 2016 Category: Toxicology Authors: Yang Y, Wang W, Xiong Z, Kong J, Qiu Y, Shen F, Huang Z Tags: Toxicol In Vitro Source Type: research

Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
This study aimed to investigate the effect of SalB on acute ethanol-induced hepatic injury in rats and to explore the role of SIRT1 in this process. The results showed that pretreatment with SalB significantly reduced ethanol-induced elevation in aminotransferase activities, decreased hepatotoxic cytokine levels such as Interleukin-6 (IL-6), and increased the antioxidant enzyme activity. Moreover, SalB pretreatment reversed the increase in NF-κB, cleaved caspase-3 and decrease in B-cell lymphoma-extra large (Bcl-xL) caused by ethanol exposure. Importantly, SalB pretreatment significantly increased the expression of SIRT1,...
Source: Toxicology Letters - April 21, 2014 Category: Toxicology Authors: Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J Tags: Toxicol Lett Source Type: research