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The Isothiocyanate Sulforaphane Depends on the Nrf2/ γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal.
The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. Neurochem Res. 2021 Jan 03;: Authors: Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dos Santos Petry F, de Oliveira MR Abstract Methylglyoxal (MG) is a reactive dicarbonyl presenting both endogenous (e.g. glycolysis) and exogenous (e.g. food cooking) sources. MG induces neurotoxicity, at least in part, by affecting mitochondrial function, including a decline in the oxidative phosphorylation (OXPHOS) system activity, bioenergetics failure, and redox disturba...
Source: Neurochemical Research - January 3, 2021 Category: Neuroscience Authors: Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dos Santos Petry F, de Oliveira MR Tags: Neurochem Res Source Type: research

Sulforaphane Promotes Mitochondrial Protection in SH-SY5Y Cells Exposed to Hydrogen Peroxide by an Nrf2-Dependent Mechanism
AbstractSulforaphane (SFN; C6H11NOS2) is an isothiocyanate found in cruciferous vegetables, such as broccoli, kale, and radish. SFN exhibits antioxidant, anti-apoptotic, anti-tumor, and anti-inflammatory activities in different cell types. However, it was not previously demonstrated whether and how this natural compound would exert mitochondrial protection experimentally. Therefore, we investigated here the effects of a pretreatment (for 30  min) with SFN at 5 μM on mitochondria obtained from human neuroblastoma SH-SY5Y cells exposed to hydrogen peroxide (H2O2) at 300  μM for 24 h. We found that SFN prevented loss of...
Source: Molecular Neurobiology - May 11, 2018 Category: Neurology Source Type: research