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Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/ Wnt inhibitory factor 1 (WIF1) axis
Conclusion: Taken together, we demonstrated that SFN could suppress the growth of NPC cells via the DNMT1/WIF1 axis.Graphical abstract
Source: Phytomedicine - July 30, 2019 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 918: Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2 α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells
Cancers, Vol. 11, Pages 918: Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells Cancers doi: 10.3390/cancers11070918 Authors: Liu Yu-Chun Chang Kuo Chen Hsu Tu Yeh Viswanadha Liao Huang Hepatocellular carcinoma (HCC) is a common fatal type of malignant tumor that has highly metastatic and recurrent properties. Fisetin is a natural flavonoid found in various vegetables and fruits which exhibits anti-cancer and anti-inflammatory properties, as well ...
Source: Cancers - June 28, 2019 Category: Cancer & Oncology Authors: Liu Yu-Chun Chang Kuo Chen Hsu Tu Yeh Viswanadha Liao Huang Tags: Article Source Type: research

Molecules, Vol. 22, Pages 1285: Fisetin Induces Apoptosis Through p53-Mediated Up-Regulation of DR5 Expression in Human Renal Carcinoma Caki Cells
Kwon Fisetin is a natural compound found in fruits and vegetables such as strawberries, apples, cucumbers, and onions. Since fisetin can elicit anti-cancer effects, including anti-proliferation and anti-migration, we investigated whether fisetin induced apoptosis in human renal carcinoma (Caki) cells. Fisetin markedly induced sub-G1 population and cleavage of poly (ADP-ribose) polymerase (PARP), which is a marker of apoptosis, and increased caspase activation. We found that pan-caspase inhibitor (z-VAD-fmk) inhibited fisetin-induced apoptosis. In addition, fisetin induced death receptor 5 (DR5) expression at the trans...
Source: Molecules - August 2, 2017 Category: Chemistry Authors: Kyoung-jin Min Ju-Ock Nam Taeg Kwon Tags: Article Source Type: research