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Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in A β25-35-induced Alzheimer's disease models in vitro.
CONCLUSIONS: These results suggest that genistein exerts a neuroprotective effect on SH-SY5Y cells in vitro via Nrf2/HO-1/PI3K signaling, providing a foundation for the application of genistein in the treatment of neurodegenerative diseases related to Nrf2/HO-1/PI3K signaling. PMID: 33605427 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - February 21, 2021 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research

The Laminin-Induced Phosphorylation of PKC δ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes.
The Laminin-Induced Phosphorylation of PKCδ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes. Cell Mol Neurobiol. 2020 Aug 26;: Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Abstract In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the endfeet that abut the blood vessels of the brain. The asymmetric distribution of this channel is dependent on the function of dystroglycan (DG), a co-expressed laminin receptor, and its associated protein complex. We have demonstrated that the addition of laminin to astrocytes in culture causes the cl...
Source: Cellular and Molecular Neurobiology - August 25, 2020 Category: Cytology Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Tags: Cell Mol Neurobiol Source Type: research