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Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1.
Abstract The omega-3 polyunsaturated fatty acids (ω3PUFAs) are a class of lipids biologically effective for the treatment of inflammatory disorders, cardiovascular disease and cancer. Patients consuming a high dietary intake of ω3PUFAs have shown a low incidence of metabolic disorders, including cancer. Although the effects of ω3PUFAs intake was shown to be involved in the prevention and treatment of these diseases, the underlying molecular mechanisms involved are not well understood. Here, we show that ω3PUFA, docosahexaenoic acid (DHA) enhanced the tumor suppressor function of LKB1. We observed that when LKB...
Source: Cancer Biology and Therapy - September 6, 2013 Category: Cancer & Oncology Authors: Andrade-Vieira R, Han JH, Marignani PA Tags: Cancer Biol Ther Source Type: research

Omega‐3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF‐7 breast cancer cells
Abstract The omega‐3 long chain polyunsaturated fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), elicit anti‐proliferative effects in cancer cell lines and in animal models. Dietary DHA and EPA can be converted to their ethanolamide derivatives, docosahexaenoyl ethanolamine (DHEA), and eicosapentaenoyl ethanolamine (EPEA), respectively; however, few studies are reported on their anti‐cancer activities. Here, we demonstrated that DHEA and EPEA were able to reduce cell viability in MCF‐7 breast cancer cells whereas they did not elicit any effects in MCF‐10A non‐tumorigenic breast epitheli...
Source: Journal of Cellular Physiology - February 25, 2013 Category: Cytology Authors: Daniela Rovito, Cinzia Giordano, Donatella Vizza, Pierluigi Plastina, Ines Barone, Ivan Casaburi, Marilena Lanzino, Francesca De Amicis, Diego Sisci, Loredana Mauro, Saveria Aquila, Stefania Catalano, Daniela Bonofiglio, Sebastiano Andò Tags: Original Research Article Source Type: research