Filtered By:
Nutrition: Omega 3

This page shows you your search results in order of date.

Order by Relevance | Date

Total 11 results found since Jan 2013.

Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress
Biochem Pharmacol. 2022 Aug 7:115203. doi: 10.1016/j.bcp.2022.115203. Online ahead of print.ABSTRACTResolvin D3 (RD3), an endogenous lipid mediator derived from omega-3 fatty acids, has been documented to attenuate inflammation in various disease models. Although it has been reported that omega-3 fatty acids attenuate metabolic disorders, the roles of RD3 in insulin signaling in skeletal muscle and hepatic lipid metabolism remain unclear. In the current study, we examined the role of RD3 in skeletal muscle insulin resistance and hepatic steatosis using in vitro and in vivo obesity models. In mouse primary hepatocytes, RD3 ...
Source: Biochemical Pharmacology - August 10, 2022 Category: Drugs & Pharmacology Authors: Heeseung Oh Wonjun Cho A M Abd El-Aty Cemil Bayram Ji Hoon Jeong Tae Woo Jung Source Type: research

Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

Omega-3 fatty acid protects cardiomyocytes against hypoxia-induced injury through targeting MiR-210-3p/CASP8AP2 axis
Mol Cell Biochem. 2021 Mar 31. doi: 10.1007/s11010-021-04141-1. Online ahead of print.ABSTRACTMicroRNAs (miRs) regulate diverse biological functions in both normal and pathological cellular conditions by post-transcriptional regulation of various genes expression. Nevertheless, the role of miRs in regulating the protective functions of omega-3 fatty acid in relation to hypoxia in cardiomyocytes remains unknown. The aim of this study was to investigate the effects of omega-3 fatty acid supplementation on cardiomyocyte apoptosis and further delineate the mechanisms underlying microRNA-210 (miRNA-210)-induced cardiomyocyte ap...
Source: Molecular and Cellular Biochemistry - April 1, 2021 Category: Biochemistry Authors: Xueju Yu Fengyao Liu Yuting Liu Bingqing Bai Han Yin Haochen Wang Yingqing Feng Huan Ma Qingshan Geng Source Type: research

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120)
Publication date: Available online 7 November 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Saeromi Kang, Jin Huang, Bo-Kyung Lee, Young-Suk Jung, Eunok Im, Jung-Min Koh, Dong-Soon Im Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepat...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 8, 2017 Category: Lipidology Source Type: research

Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).
Abstract Protective effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-alcoholic fatty liver disease has been demonstrated. FFA4 (also known as GPR120; a G protein-coupled receptor) has been suggested to be a target of n-3 PUFA. FFA4 expression in hepatocytes has also been reported from liver biopsies in child fatty liver patients. In order to assess the functional role of FFA4 in hepatic steatosis, we used an in vitro model of liver X receptor (LXR)-mediated hepatocellular steatosis. FFA4 expression was confirmed in Hep3B and HepG2 human hepatoma cells. T0901317 (a specific LXR activator) induced lip...
Source: Biochimica et Biophysica Acta - November 7, 2017 Category: Biochemistry Authors: Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS Tags: Biochim Biophys Acta Source Type: research

Inhibitory effects of Omega-3 fatty acids on Early Brain Injury after Subarachnoid Hemorrhage in Rats: possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway.
This study was to examine the effects of omega-3 fatty acids on SAH-induced EBI. Two weeks before SAH, 30% Omega-3 fatty acids was administered by oral gavage at 1g/kg body weight once every 24hours. Specific siRNA for GPR120 was exploited. Terminal deoxynucleotidyl transferase dUTP nick end labeling, fluoro-Jade B staining, and neurobehavioral scores and brain water content test showed that omega-3 fatty acids effectively suppressed SAH-induced brain cell apoptosis and neuronal degradation, behavioral impairment, and brain edema. Western blot, immunoprecipitation, and electrophoretic mobility shift assays results showed t...
Source: The International Journal of Biochemistry and Cell Biology - March 17, 2016 Category: Biochemistry Authors: Yin J, Li H, Meng C, Chen D, Chen Z, Wang Y, Wang Z, Chen G Tags: Int J Biochem Cell Biol Source Type: research

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1.
Abstract The omega-3 polyunsaturated fatty acids (ω3PUFAs) are a class of lipids biologically effective for the treatment of inflammatory disorders, cardiovascular disease and cancer. Patients consuming a high dietary intake of ω3PUFAs have shown a low incidence of metabolic disorders, including cancer. Although the effects of ω3PUFAs intake was shown to be involved in the prevention and treatment of these diseases, the underlying molecular mechanisms involved are not well understood. Here, we show that ω3PUFA, docosahexaenoic acid (DHA) enhanced the tumor suppressor function of LKB1. We observed that when LKB...
Source: Cancer Biology and Therapy - September 6, 2013 Category: Cancer & Oncology Authors: Andrade-Vieira R, Han JH, Marignani PA Tags: Cancer Biol Ther Source Type: research

Omega‐3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF‐7 breast cancer cells
Abstract The omega‐3 long chain polyunsaturated fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), elicit anti‐proliferative effects in cancer cell lines and in animal models. Dietary DHA and EPA can be converted to their ethanolamide derivatives, docosahexaenoyl ethanolamine (DHEA), and eicosapentaenoyl ethanolamine (EPEA), respectively; however, few studies are reported on their anti‐cancer activities. Here, we demonstrated that DHEA and EPEA were able to reduce cell viability in MCF‐7 breast cancer cells whereas they did not elicit any effects in MCF‐10A non‐tumorigenic breast epitheli...
Source: Journal of Cellular Physiology - February 25, 2013 Category: Cytology Authors: Daniela Rovito, Cinzia Giordano, Donatella Vizza, Pierluigi Plastina, Ines Barone, Ivan Casaburi, Marilena Lanzino, Francesca De Amicis, Diego Sisci, Loredana Mauro, Saveria Aquila, Stefania Catalano, Daniela Bonofiglio, Sebastiano Andò Tags: Original Research Article Source Type: research