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Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells
Nutr Cancer. 2021 Jul 19:1-14. doi: 10.1080/01635581.2021.1952628. Online ahead of print.ABSTRACTIn the present study, we have explored the prognostic value of HuR gene as well as protein in breast cancers. Furthermore, we have also investigated the HuR therapeutic relevance in TNBCs, which is an aggressive breast cancer subtype. Using an online meta-analysis tool, we found that HuR protein overexpression positively correlates with reduced overall survival of TNBC patients (p = 0.028). Furthermore, we demonstrated that the TNBC breast cancer cell lines i.e., MDA-MB-231 and MDA-MB-468 are good model systems to study HuR pro...
Source: Nutrition and Cancer - July 19, 2021 Category: Cancer & Oncology Authors: Sheikh Mohammad Umar Sushmita Patra Akanksha Kashyap Arundhathi Dev J R Lalit Kumar Chandra Prakash Prasad Source Type: research

Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells.
Abstract Cancer stem cell theory has been proposed to explain tumor heterogeneity and the carcinogenesis process. Highly tumorigenic lung cancer stem cells develop resistance to cisplatin (CDDP), a common chemotherapy drug. Herein, we attempted to clarify whether apigenin (API) can improve the antitumor efficiency of CDDP in lung cancer using cancer stem cells. Lung cancer stem cells were identified as CD 133 positive cancer cells in non-small cell lung cancer (NSCLC) A549, H1299 cells and CDDP-resistant NSCLC A549R cells. The cytotoxic effect of API was measured in CDDP-treated A549, H1299, and A549R cells. API r...
Source: Nutrition and Cancer - August 5, 2020 Category: Cancer & Oncology Authors: Li Y, Chen X, He W, Xia S, Jiang X, Li X, Bai J, Li N, Chen L, Yang B Tags: Nutr Cancer Source Type: research

TRIM13 inhibits cell migration and invasion in clear-cell renal cell carcinoma.
This study explored the clinical significance and biological function of TRIM13 in human RCC. Western blot analyses and Immunohistochemical were performed in RCC tissues. The clinical relevance of TRIM13 in RCC was evaluated by immunohistochemical staining using tissue microarray. The role of TRIM13 in migration was studied in renal cell carcinoma cell lines of 786-O through knocking down TRIM13 with siRNA and over-expression of TRIM13. The regulation of TRIM13 on migration and invasion were determined by wound-healing and transwell assays. Western blot analyses showed that TRIM13 expression was dramatically decreased in R...
Source: Nutrition and Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Li H, Qu L, Zhou R, Wu Y, Zhou S, Zhang Y, Cheng B, Ni J, Huang H, Hou J Tags: Nutr Cancer Source Type: research

Oleic acid promotes cell invasion through an integrin-linked kinase signaling pathway in renal cell carcinoma.
In this study, we further observe the effects of OA on cell invasion of RCC and the potential mechanism by which OA worked was determined. The transwell invasion assay showed OA increased cell invasion of RCC in a dose-dependent manner. Western blotting results indicated ILK, COX-2, and MMP-9 proteins were involved for their high expressions and these effects were reversed when down-regulating the expression of ILK by special siRNA. The MMPs inhibitor GM6001 could weaken the abilities of OA on RCC cells invasion. These results suggested MUFA indeed affected cell invasion of RCC, which was depended by the regulation of ILK ...
Source: Nutrition and Cancer - September 30, 2019 Category: Cancer & Oncology Authors: Liu ZH, Qing CP, Sheng ZZ, Li GZ, Man LB, Xu T Tags: Nutr Cancer Source Type: research

PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Vitamin C Prevents Hydrocortisone-Induced Injury in HMEC-1 through Promoting Bestrophin-3 Expression.
CONCLUSIONS: VC can efficiently attenuate HC-induced HMEC-1 cell injury, which may be related to promote Best-3 expression. PMID: 30672332 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - January 23, 2019 Category: Cancer & Oncology Authors: Wang X, Zhang G, Zhu C, Lin L, Zhao Z, Yu X, Liu G, Zhang H, Li Q, Dong W, Wang J Tags: Nutr Cancer Source Type: research

Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2.
This study demonstrates that the antiproliferative effect of quercetin on HCC cells can be mediated by reducing intracellular ROS, which is independent of p53 expression. PMID: 30661409 [PubMed - as supplied by publisher]
Source: Nutrition and Cancer - January 19, 2019 Category: Cancer & Oncology Authors: Jeon JS, Kwon S, Ban K, Kwon Hong Y, Ahn C, Sung JS, Choi I Tags: Nutr Cancer Source Type: research