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Butyrate Improves Porcine Endometrial Epithelial Cell Receptivity via Enhancing Acetylation of Histone H3K9
CONCLUSION: The findings reveal that butyrate improves endometrial epithelial cell receptivity by enhancing the acetylation of histone H3K9, which shows nutritional regulation and therapeutic potential for poor uterine receptivity and difficulty in embryo implantation.PMID:37417211 | DOI:10.1002/mnfr.202200703
Source: Cell Research - July 7, 2023 Category: Cytology Authors: Qianhong Ye Haoyu Li Baoyang Xu Ziyi He Xianghua Yan Source Type: research

A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
Abstract Almost a billion people worldwide are chronically undernourished. Herein, using a mouse model of coxsackievirus B3 (CVB3) infection, we report that a single day of food restriction (FR) markedly increases susceptibility to attenuated enterovirus infection, replication, and disease. These "pro-viral" effects, which are rapidly-reversed by the restoration of food, are mediated by several genes whose expression is altered by FR, and which support CVB3 replication. Central to this is TFEB, a protein whose expression and activation status are rapidly increased by FR. TFEB, which regulates the transcription of ...
Source: Autophagy - February 3, 2020 Category: Cytology Authors: Alirezaei M, Flynn CT, Garcia SD, Kimura T, Whitton JL Tags: Autophagy Source Type: research

Oxymatrine Inhibits Homocysteine-Mediated Autophagy via MIF/mTOR Signaling in Human Umbilical Vein Endothelial Cells
Conclusions: These results suggest that Hcy can evokeautophagy-activated HUVEC apoptosis/death via a MIF/mTOR signaling pathway, which can be reversed by OMT. Our results provide a new insight into a functional role of OMT in the prevention of Hcy-induced HUVEC injury and death.Cell Physiol Biochem 2018;45:1893 –1903
Source: Cellular Physiology and Biochemistry - March 6, 2018 Category: Cytology Source Type: research