• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Biomedical application of Chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy
Publication date: Available online 16 February 2021Source: Carbohydrate PolymersAuthor(s): Milad Ashrafizade, Masoud Delfi, Farid Hashemi, Amirhossein Zabolian, Hossein Saleki, Morteza Bagherian, Negar Azami, Mahdi Vasheghani Farahani, Seyed omid Sharifzadeh, Soodeh Hamzehlou, Kiavash Hushmandi, Pooyan Makvandi, Ali Zarrabi, Michael R. Hamblin, Rajender S. Varma
Source: Carbohydrate Polymers - February 17, 2021 Category: Biomedical Science Source Type: research

Chitosan based pH-responsive polymeric prodrug vector for enhanced tumor targeted co-delivery of doxorubicin and siRNA
Publication date: Available online 29 July 2020Source: Carbohydrate PolymersAuthor(s): Tingsheng Yan, Siyuan Zhu, Wenxue Hui, Jinmei He, Zhonghua Liu, Jinju Cheng
Source: Carbohydrate Polymers - July 31, 2020 Category: Biomedical Science Source Type: research

Cationic Cellulose Nanocrystals Complexed with Polymeric siRNA for Efficient Anticancer Drug Delivery
Publication date: Available online 25 June 2020Source: Carbohydrate PolymersAuthor(s): Young Min Kim, Yoon Suk Lee, Taehyung Kim, Kyungjik Yang, Keonwook Nam, Deokyeong Choe, Young Hoon Roh
Source: Carbohydrate Polymers - June 27, 2020 Category: Biomedical Science Source Type: research

Dextran-based coacervate nanodroplets as potential gene carriers for efficient cancer therapy
Publication date: Available online 29 November 2019Source: Carbohydrate PolymersAuthor(s): Wang Chenglong, Xiong Shuhan, You Jiayi, Guan Wencai, Xu Guoxiong, Dou HongjingAbstractThe intractable toxicity of cationic polymers limits their applicability in gene transport and controlled release. In consideration of the good biocompatibility and biofunctionality of dextran, herein we design and synthesize two types of amino group-containing cationic copolymers based on dextran by the copolymerization of cationic monomers from dextran backbones. Additionally, allyl crosslinkers containing disulfide bonds were introduced into pol...
Source: Carbohydrate Polymers - December 1, 2019 Category: Biomedical Science Source Type: research

Preparation and Cell Activities of Lactosylated Curdlan-triornithine Nanoparticles for Enhanced DNA/siRNA Delivery in Hepatoma Cells
Publication date: Available online 27 August 2019Source: Carbohydrate PolymersAuthor(s): Xia Wang, Yuxuan Qi, Lixia Liu, Tsogzolmaa Ganbold, Huricha Baigude, Jingfen HanAbstractA long-anticipated cancer therapy would deliver the right type of therapeutic agents to the target in control with minimal systemic toxicity. The purpose of this study was to prepare lactosylated curdlan-triornithine nanocarriers (CTOLs), and target deliver gene to hepatoma cells. Structures and biophysical properties had been elucidated with physical and chemical methods. The results revealed that those functionalized polymers can completely conden...
Source: Carbohydrate Polymers - August 28, 2019 Category: Biomedical Science Source Type: research

Advances in Chitosan-based Nanoparticles for Oncotherapy
Publication date: Available online 19 June 2019Source: Carbohydrate PolymersAuthor(s): Enhui Zhang, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Pengcheng LiAbstractChitosan has attracted considerable attention as an anti-tumor drug carrier material in recent years, which is due to its biocompatibility and biodegradability, as well as the simple and mild preparing techniques of drug-loaded nanoparticles. Chitosan-based nanoparticles can deliver various anti-tumor agents to specific tumor tissues by passive and active targeting mechanisms, including traditional chemotherapeutic agents, DNA or siRNA, proteins, photosensitize...
Source: Carbohydrate Polymers - June 19, 2019 Category: Biomedical Science Source Type: research

Amphipathic Chitosans Improve the Physicochemical Properties of siRNA-Chitosan Nanoparticles at Physiological Conditions
In this study, a series of amphipathic chitosans were synthesized by varying the degree of acetylation (DA) from ˜2 to ˜30 mol% and the degree of substitution (DS) from 5 to 25%. by tertiary amino groups (DEAE) The results showed that the adjustment of these parameters decreases the interparticle interactions mediated by hydrogen bonding to obtain nanoparticles with improved colloidal stability. siRNA-containing nanoparticles of 100 to 150 nm with low polydispersities (0.15-0.2) and slightly positive zeta potentials (˜ + 5 mV) were resistant to aggregation at pH 7.4 and ionic strength of 150 mM. This resista...
Source: Carbohydrate Polymers - March 29, 2019 Category: Biomedical Science Source Type: research

Carbohydrate response element binding protein (ChREBP) modulates the inflammatory response of mesangial cells in response to glucose.
Abstract Diabetic nephropathy (DN) is one of the most devastating complications of diabetes mellitus. Carbohydrate response element binding protein (ChREBP) is a basic helix-loop-helix leucine zipper transcription factor that primarily mediates glucose homeostasis in the body. The present study investigated the role of ChREBP in the pathogenesis of DN. The expression of ChREBP was detected in patients with type 2 diabetes mellitus (T2DM), diabetic mice and mesangial cells. ELISA was used to measure cytokine production in mesangial cells. Flow cytometry analysis was performed to detect the apoptosis of mes...
Source: Bioscience Reports - November 12, 2018 Category: Biomedical Science Authors: Chen Y, Wang YJ, Zhao Y, Wang JC Tags: Biosci Rep Source Type: research

A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy
In this study, we synthesized a hyaluronan-based ROS-sensitive polymer which was expected to release loaded chemical drugs in inflammatory environment and further developed a stable and nontoxic co-delivery nanosystem of siRNA targeting autophagy suppressive gene and chemotherapeutic agents. The in vitro transfection study of this nanosystem revealed improved intracellular accumulation of siRNA and excellent gene silencing efficacy comparable to that of conventional cationic liposome. Moreover, the mRNA expression of inflammatory cytokines was remarkably decreased by our nanosystem. Considering its biocompatibility, transf...
Source: Carbohydrate Polymers - May 3, 2018 Category: Biomedical Science Source Type: research

GABAB receptor ligand-directed trimethyl chitosan/tripolyphosphate nanoparticles and their pMDI formulation for survivin siRNA pulmonary delivery
Publication date: 1 January 2018 Source:Carbohydrate Polymers, Volume 179 Author(s): Suhui Ni, Yun Liu, Yue Tang, Jing Chen, Shuhan Li, Ji Pu, Lidong Han The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis of lung tumor has been attracted more interest. GABAB receptor ligand-directed nanoparticles consisting of baclofen functionalized trimethyl chitosan (Bac-TMC) as polymeric carriers, tripolyphosphate (TPP) as ionic crosslinker, and siSurvivin as therapeutic genes, were designed to enhance the survivin gene silencing. GABAB receptor agonist baclofen (Bac) was initially introduce...
Source: Carbohydrate Polymers - October 2, 2017 Category: Biomedical Science Source Type: research