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Melatonin MT < sub > 2 < /sub > receptor is expressed and potentiates contraction in human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 6. doi: 10.1152/ajplung.00273.2021. Online ahead of print.ABSTRACTNocturnal asthma is characterized by heightened bronchial reactivity at night, and plasma melatonin concentrations are higher in patients with nocturnal asthma symptoms. Numerous physiological effects of melatonin are mediated via its specific G protein-coupled receptors (GPCRs) named the MT1 receptor which couples to both Gq and Gi proteins, and the MT2 receptor which couples to Gi. We investigated whether melatonin receptors are expressed on airway smooth muscle, whether they regulate intracellular cyclic AMP (c...
Source: Am J Physiol Lung Ce... - October 6, 2021 Category: Respiratory Medicine Authors: Haruka Sasaki Yi Zhang Charles W Emala Kentaro Mizuta Source Type: research

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling
Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print.ABSTRACTExaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors (GPCRs) causes airway hyperresponsiveness (AHR) in asthma. Activation of Gq-coupled GPCRs leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP3) and diacylglycerol (DAG). DAG signaling is terminated by the action of DAG kinase (DGK) that converts DAG into phosphatidic acid (PA). Our previous study demonstrated that DGKα and ζ isoform knockout mice are protected from the development of all...
Source: Am J Respir Cell Mol... - July 22, 2021 Category: Respiratory Medicine Authors: Pawan Sharma Santosh K Yadav Sushrut D Shah Elham Javed John M Lim Shi Pan Ajay P Nayak Reynold A Panettieri Raymond B Penn Taku Kambayashi Deepak A Deshpande Source Type: research

Store-operated Calcium Entry-associated Regulatory Factor Regulates Airway Inflammation and Airway Remodeling in Asthma Mice Models
CONCLUSIONS: SARAF plays a protective role against airway inflammation and remodeling in asthma mice models by blunting SOCE; SARAF may also be a functional regulating factor of hASMCs.PMID:34231388 | DOI:10.1152/ajplung.00079.2020
Source: Am J Physiol Lung Ce... - July 7, 2021 Category: Respiratory Medicine Authors: Yi-Min Wang Wen-Juan Xu Lin-Li Xiang Mei Ding Jin-Jin Zhang Jing-Ya Lu Bao-Juan Xie Ya-Dong Gao Source Type: research

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