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Metformin reverses oxidative stress ‑induced mitochondrial dysfunction in pre‑osteoblasts via the EGFR/GSK‑3β/calcium pathway
Int J Mol Med. 2023 Apr;51(4):36. doi: 10.3892/ijmm.2023.5239. Epub 2023 Mar 31.ABSTRACTOxidative stress is one of the main causes of osteoblast apoptosis induced by post‑menopausal osteoporosis. The authors previously found that metformin can reverse the loss of bone mass in post‑menopausal osteoporosis. The present study aimed to further clarify the effects and mechanisms of action of metformin in post‑menopausal osteoporosis under conditions of oxidative stress. Combined with an in‑depth investigation using the transcriptome database, the association between oxidative stress and mitochondrial dysfunction in post...
Source: International Journal of Molecular Medicine - March 31, 2023 Category: Molecular Biology Authors: Fangming Cao Keda Yang Shui Qiu Jie Li Wen Jiang Lin Tao Yue Zhu Source Type: research

Metformin ameliorates TGF- β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling.
In conclusion, our results suggest a beneficial effect of metformin based on the prevention of osteoblastic differentiation of human AVICs via inhibition of β-catenin, which indicates the therapeutic potential of metformin for CAVD. PMID: 29679571 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - April 18, 2018 Category: Biochemistry Authors: Fayuan L, Chong C, Qinyu W, Shi Jiawei, Huadong L, Nianguo D Tags: Biochem Biophys Res Commun Source Type: research