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SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research

The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca2+ in regulating SMC function. Increased intracellular calcium concentration ([Ca2+]i) in vascular SMC has been proposed to stimulate VC. However, the contribution of the non-selective Piezo1 mechanosensitive cation channels to the elevation of [Ca2+]i, and consequently to the process of VC has never been examined. In this work the essential contribution of Piezo1 channels to arterial medial cal...
Source: Frontiers in Physiology - November 10, 2022 Category: Physiology Source Type: research

25-hydroxyvitamin D-1 α-hydroxylase (CYP27B1) induces ectopic calcification
J Clin Biochem Nutr. 2022 Sep;71(2):103-111. doi: 10.3164/jcbn.22-16. Epub 2022 Jun 4.ABSTRACTVascular calcification is an important pathogenesis related to cardiovascular disease and high mortality rate in chronic kidney disease (CKD) patients. It has been well-known that hyper-phosphatemia induces osteochondrogenic transition of vascular smooth muscle cells (VSMCs) resulting ectopic calcification in aortic media, cardiac valve, and kidney. However, the detailed mechanism of the ectopic calcification has been not clarified yet. Here, we found that the co-localization of CYP27B1 with the calcified lesions of aorta and arte...
Source: Journal of Clinical Biochemistry and Nutrition - October 10, 2022 Category: Nutrition Authors: Yilimulati Yimamu Ayako Ohtani Yuichiro Takei Airi Furuichi Yuki Kamei Hisami Yamanaka-Okumura Hirokazu Ohminami Masashi Masuda Makoto Miyazaki Hironori Yamamoto Yutaka Taketani Source Type: research

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