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Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-¿B activation in cultured astrocytes and microglial BV-2 cells
Conclusions: These results indicated that ent-Sauchinone inhibited neuroinflammation and amyloidogenesis through the inhibition of STAT3-mediated NF-kappaB activity, and thus could be applied in the treatment of neuro-inflammatory diseases, including Alzheimer's disease.
Source: Journal of Neuroinflammation - July 2, 2014 Category: Neurology Authors: Suk-Young SongYu JungChul HwangHee LeeChang SokJoo KimSang LeeHyun SeoByung HyunDong ChoiSang HanYoung HamBang HwangJin Hong Source Type: research

miR-Synth: a computational resource for the design of multi-site multi-target synthetic miRNAs
RNAi is a powerful tool for the regulation of gene expression. It is widely and successfully employed in functional studies and is now emerging as a promising therapeutic approach. Several RNAi-based clinical trials suggest encouraging results in the treatment of a variety of diseases, including cancer. Here we present miR-Synth, a computational resource for the design of synthetic microRNAs able to target multiple genes in multiple sites. The proposed strategy constitutes a valid alternative to the use of siRNA, allowing the employment of a fewer number of molecules for the inhibition of multiple targets. This may represe...
Source: Nucleic Acids Research - May 19, 2014 Category: Research Authors: Lagana, A., Acunzo, M., Romano, G., Pulvirenti, A., Veneziano, D., Cascione, L., Giugno, R., Gasparini, P., Shasha, D., Ferro, A., Croce, C. M. Tags: Computational Biology Source Type: research

Metastatic prostate cancer cell-specific phage-like particles as a targeted gene-delivery system
Conclusion: Successful employment of phage-like particles expressing emerald green fluorescent protein genes targeted to prostate cancer cells PC-3M confirms a prospect of their use for targeted delivery of therapeutic genes to cancer cells.
Source: Journal of Nanobiotechnology - September 23, 2013 Category: Nanotechnology Authors: Olusegun FagbohunRobert KazmierczakValery PetrenkoAbraham Eisenstark Source Type: research

Differential regulation of HIF‐mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts.
Abstract Inappropriate osteoclast activity instigates pathological bone loss in rheumatoid arthritis. We have investigated how osteoclasts generate sufficient ATP for the energy‐intensive process of bone resorption in the hypoxic microenvironment associated with this rheumatic condition. We show that in human osteoclasts differentiated from CD14+ monocytes hypoxia (24h, 2% O2) (i) increases ATP production and mitochondrial electron transport chain activity (Alamar Blue, O2 consumption); (ii) increases glycolytic flux (glucose consumption, lactate production) and (iii) increases glutamine consumption. We demonstrate that ...
Source: The Journal of Pathology - January 1, 2013 Category: Pathology Authors: Karl J Morten, Luned Badder, Helen J Knowles Tags: Original Paper Source Type: research

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