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Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN
This study investigated the impacts of caffeine and theophylline on gastric cancer cell apoptosis and autophagy using a gastric cancer cell line (MGC-803) and a nude mouse model. Peritumoural and tumour tissues were collected from five patients diagnosed with gastric carcinoma who underwent laparoscopic radical gastrectomy at our hospital. Autophagy was suppressed in gastric cancer tumour tissue compared with peritumoural tissue. In vitro, both caffeine and theophylline effectively suppressed MGC-803 cell proliferation and migration and induced autophagy. To assess the involvement of PTEN in caffeine-mediated and theophyll...
Source: Anti-Cancer Drugs - March 16, 2019 Category: Cancer & Oncology Tags: PRECLINICAL REPORTS Source Type: research

Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma.
Authors: Kataoka J, Shiraha H, Horiguchi S, Sawahara H, Uchida D, Nagahara T, Iwamuro M, Morimoto H, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Takaki A, Nouso K, Yagi T, Yamamoto K, Okada H Abstract Runt-related transcription factor 3 (RUNX3) is known to function as a tumor suppressor in gastric cancer and other types of cancers, including hepatocellular carcinoma (HCC). However, its role has not been fully elucidated. In the present study, we aimed to evaluate the role of RUNX3 in HCC. We used the human HCC cell lines Hep3B, Huh7 and HLF; RUNX3 cDNA was introduced into Hep3B and Huh7 cells, which were negative f...
Source: Oncology Reports - March 19, 2016 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-216b is Down-Regulated in Human Gastric Adenocarcinoma and Inhibits Proliferation and Cell Cycle Progression by Targeting Oncogene HDAC8
We reported a significantly decreased expression of miR-216b in GC clinical specimens compared with paired non-cancerous tissues. We also observed a significant down-regulation of miR-216b expression in GC cell lines AGS and GC9811 (p < 0.0001). The introduction of miR-216b suppressed GC cell proliferation and cell cycle progression by targeting HDAC8, an oncogene shown to promote malignant tumor development with a potential miR-216b binding site in its 3′ untranslated region. HDAC8 expression was shown to be significantly increased in AGS and GC9811 cell lines (p < 0.0001) and GC tissues compared with cont...
Source: Targeted Oncology - September 26, 2015 Category: Cancer & Oncology Source Type: research

Abstract 596: DKK3 expression and its function in head and neck squamous cell carcinoma
In this study, 90 cases of HNSCC tissue samples, which were obtained from Okayama University hospital with written informed consent, for immunohistochemistry to examine DKK3 protein expression. The protein expression status was scored as positive or negative. Pearson's Chi-square test and Fisher's exact test were used to evaluate the correlation between the DKK3 protein expression and clinicopathological characteristics. Kaplan-Meier analysis was performed to determine the survival analysis. For functional analyses, HNSCC-derived cells were used. Gastric and colorectal cancer cell lines were also used for comparison. DKK3 ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Katase, N., Gunduz, M., Tsujigiwa, H., Ito, S., Fujii, M., Nagatsuka, H., Sasaki, A., Nohno, T. Tags: Molecular and Cellular Biology Source Type: research