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Eukaryotic Clathrin Adapter Protein and Mediator of Cholesterol Homeostasis, PICALM, Affects Trafficking to the Chlamydial Inclusion
Mol Cell Biol. 2023 Feb 13:1-13. doi: 10.1080/10985549.2023.2171695. Online ahead of print.ABSTRACTThe obligate intracellular pathogen Chlamydia trachomatis has unique metabolic requirements as it proceeds through its biphasic developmental cycle from within the inclusion within the host cell. In our previous study, we identified a host protein, PICALM, which localizes to the chlamydial inclusion. PICALM functions in many host pathways including the recycling of receptors, specific SNARE proteins, and molecules like transferrin, and maintaining cholesterol homeostasis. Hence, we hypothesized that PICALM functions to mainta...
Source: Mol Biol Cell - February 13, 2023 Category: Molecular Biology Authors: Lisa M Jorgenson Lindsey Knight Ray E Widner Elizabeth A Rucks Source Type: research

Identification of proteins interacting with pORF5 in the pathogenesis of C. trachomatis.
CONCLUSION: Identification of key proteins interacting with pORF5 could contribute to the understanding and further exploration of the function of pORF5 in the pathogenic mechanisms of C. trachomatis. PMID: 30018706 [PubMed]
Source: American Journal of Translational Research - July 19, 2018 Category: Research Tags: Am J Transl Res Source Type: research

Synergistic Costimulatory Effect of Chlamydia pneumoniae with Carbon Nanoparticles on NLRP3 Inflammasome-Mediated Interleukin-1{beta} Secretion in Macrophages Host Response and Inflammation
This study assessed whether costimulation of C. pneumoniae with CNTs synergistically enhanced IL-1β secretion from macrophages, and determined the molecular mechanism involved. Enhanced IL-1β secretion from C. pneumoniae-infected macrophages by CNTs was dose and time dependent. Transmission electron microscopy revealed that C. pneumoniae and CNTs were engulfed concurrently by macrophages. Inhibitors of actin polymerization or caspase-1, a component of the inflammasome, significantly blocked IL-1β secretion. Gene silencing using small interfering RNA (siRNA) targeting the NLRP3 gene also abolished IL-1β ...
Source: Infection and Immunity - June 15, 2015 Category: Infectious Diseases Authors: Matsuo, J., Nakamura, S., Takeda, S., Ishida, K., Yamazaki, T., Yoshida, M., Chiba, H., Hui, S.-P., Yamaguchi, H. Tags: Host Response and Inflammation Source Type: research

Chlamydia pneumoniae effector chlamydial outer protein N sequesters fructose bisphosphate aldolase A, providing a benefit to bacterial growth
Conclusions: We discovered that one of the C. pneumoniae CopN targets is the glycolytic enzyme aldolase A. Sequestering aldolase A may be beneficial to bacterial growth in infected host cells.
Source: BMC Microbiology - December 21, 2014 Category: Microbiology Authors: Kasumi IshidaJunji MatsuoYoshimasa YamamotoHiroyuki Yamaguchi Source Type: research

Host metabolism promotes growth of Chlamydia pneumoniae in a low oxygen environment.
Abstract Chlamydia pneumoniae infections of the respiratory tract are common and are associated with acute and chronic diseases such as community-acquired pneumonia (CAP) and chronic obstructive pulmonary disease (COPD). Recent studies have shown that reduced environmental oxygen availability promotes chlamydial growth in infected host cells. The underlying mechanisms remain unclear. We performed a targeted siRNA screen coupled with an automated high-throughput microscopic analysis to identify key host cell genes that play a role in promoting the hypoxic growth of C. pneumoniae. A total of 294 siRNAs - targeting 9...
Source: International Journal of Medical Microbiology - April 6, 2013 Category: Microbiology Authors: Szaszák M, Shima K, Käding N, Hannus M, Solbach W, Rupp J Tags: Int J Med Microbiol Source Type: research