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SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Role of the histone H3 lysine 9 methyltransferase Suv39 h1 in maintaining Epsteinn–Barr virus latency in B95–8 cells
The ability of Epstein–Barr Virus (EBV) to establish latent infection is associated with infectious mononucleosis and a number of malignancies. In EBV, the product of the BZLF1 gene (ZEBRA) acts as a master regulator of the transition from latency to the lytic replication cycle in latently infected cells. EBV latency is primarily maintained by hypoacetylation of histone proteins in the BZLF1 promoter by histone deacetylases. Although histone methylation is involved in the organization of chromatin domains and has a central epigenetic role in gene expression, its role in maintaining EBV latency is not well understood. Her...
Source: FEBS Journal - March 17, 2014 Category: Research Authors: Kenichi Imai, Noriaki Kamio, Marni E. Cueno, Yuko Saito, Hiroko Inoue, Ichiro Saito, Kuniyasu Ochiai Tags: Original Article Source Type: research

Role of the histone H3 lysine 9 methyltransferase Suv39h1 in maintaining Epstein–Barr virus latency in B95‐8 cells
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - March 4, 2014 Category: Research Authors: Kenichi Imai, Noriaki Kamio, Marni E. Cueno, Yuko Saito, Hiroko Inoue, Ichiro Saito, Kuniyasu Ochiai Tags: Original Article Source Type: research