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Matrix metalloproteinase-2 delivery to extracellular vesicles produced by HPV-positive cervical cancer cells enhances metastasis via the Akt pathway
Cell Biol Int. 2023 Jun 5. doi: 10.1002/cbin.12054. Online ahead of print.ABSTRACTHere, we aimed to analyze the effects of matrix metalloproteinase-2 (MMP-2) delivery to extracellular vesicles (EVs) secreted by human papillomavirus (HPV)-associated cervical cancer cells on human umbilical vein endothelial cell (HUVEC) angiogenesis. First, MMP-2 expression was compared among SiHa (HPV16), HeLa (HPV18), and C-33A (negative) cells. Then, EVs were isolated from these cells, and MMP-2 expression in the EVs was compared. SiHa and HeLa cells were transfected with MMP-2 or control siRNA. HUVECs were treated with EVs isolating from...
Source: Cell Biology International - June 5, 2023 Category: Cytology Authors: Jianan Sun Junjun Mou Yunmei Zhang Kang Yuan Ying Yang Qing Tang Source Type: research

Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts
CONCLUSIONS: The downregulation of the SHh signaling promotes HPV replication and the formation of warts by inducing G2/M arrest in the keratinocytes of CA.PMID:36704875 | DOI:10.1111/srt.13265
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Xiangxi Du Shan Li Kun Yang Yuchun Cao Source Type: research

The Significance of CD109 Expression in Oropharyngeal Squamous Cell Carcinoma
CONCLUSION: CD109 expression is associated with poor prognosis of HPV16+ OPSCCs.PMID:35347029 | DOI:10.21873/anticanres.15687
Source: Cell Research - March 29, 2022 Category: Cytology Authors: Shohei Tsutsumi Kaho Momiyama Masaaki Ichinoe Takuya Kato Sachiyo Mogi Shunsuke Miyamoto Yoshiki Murakumo Taku Yamashita Source Type: research

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cell Research - February 11, 2022 Category: Cytology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research

The PPARβ agonist L-165041 promotes VEGF mRNA stabilization in HPV18-harboring HeLa cells through a receptor-independent mechanism.
Abstract Peroxisome Proliferator-Activated Receptor-β (PPARβ) is a ligand-inducible transcription factor activated by both natural (fatty acids and derivatives) and high affinity synthetic agonists. It is thought to play a role in angiogenesis development and Vascular Endothelial Growth Factor (VEGF) regulation but its contribution remains unclear. Until now, PPARβ agonism effect on VEGF expression in cervical cancer cells was unknown. This led to our interest in assessing the effect of PPARβ activation on the regulation of different VEGF isoforms mRNA expression and the impact of E6 viral oncoprotein and its ...
Source: Cellular Signalling - October 27, 2013 Category: Cytology Authors: Roche E, Lascombe I, Bittard H, Mougin C, Fauconnet S Tags: Cell Signal Source Type: research