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Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR- γ and SOCS1 induction.
Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction. J Clin Biochem Nutr. 2020 Nov;67(3):248-256 Authors: Park JM, An JM, Han YM, Surh YJ, Hwang SJ, Kim SJ, Hahm KB Abstract The health beneficial effects of walnut plentiful of n-3 polyunsaturated fatty acid had been attributed to its anti-inflammatory and anti-oxidative properties against various clinical diseases. Since we have published Fat-1 transgenic mice overexpressing 3-desaturase significantly mitigated Helicobacter pylori (H. pylori)-associated gastric pat...
Source: Journal of Clinical Biochemistry and Nutrition - December 11, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
In conclusion, DHA inhibits H. pylori‐induced STAT3 phosphorylation in a PPARγ/SOCS3‐dependent manner. This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 31, 2016 Category: Nutrition Authors: Hyeon‐Geun Ji, Juan‐Yu Piao, Su‐Jung Kim, Do‐Hee Kim, Ha‐Na Lee, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Helicobacter pylori induces Snail expression through ROS‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 26, 2016 Category: Molecular Biology Authors: Hoang‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research

Helicobacter pylori induces Snail expression through ROS ‐mediated activation of Erk and inactivation of GSK‐3β in human gastric cancer cells
Helicobacter pylori (H. pylori) infection has been known to be implicated in human gastric carcinogenesis. Snail, the zinc‐finger transcription factor known as a key inducer of changes in the cell shape and morphogenetic movement, is aberrantly overexpressed and correlates with lymph node metastasis in gastric cancer. In the present study, we investigated whether H. pylori could induce Snail activation to provoke these changes. Using a cell scatter assay, we noticed that human gastric cancer AGS cells infected with H. pylori underwent morphological changes as well as disruption of cell–cell interaction, which was then ...
Source: Molecular Carcinogenesis - January 24, 2016 Category: Molecular Biology Authors: Hoang ‐Kieu‐Chi Ngo, Hee Geum Lee, Juan‐Yu Piao, Xiancai Zhong, Ha‐Na Lee, Hyeong‐Jun Han, Wonki Kim, Do‐Hee Kim, Young‐Nam Cha, Hye‐Kyung Na, Young‐Joon Surh Tags: Research Article Source Type: research