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Examination of the genetic basis for sexual dimorphism in the Aedes aegypti (dengue vector mosquito) pupal brain
Conclusions These studies revealed sex-specific gene expression profiles in the developing A. aegypti pupal head and identified Doublesex as a key regulator of sexually dimorphic gene expression during mosquito neural development.
Source: Biology of Sex Differences - October 21, 2014 Category: Biology Source Type: research

Kinome siRNA screen identifies novel cell-type specific dengue host target genes.
Abstract Dengue is a global emerging infectious disease, with no specific treatment available. To identify novel human host cell targets important for dengue virus infection and replication, an image-based high-throughput siRNA assay screening of a human kinome siRNA library was conducted using human hepatocyte cell line Huh7 infected with a recent dengue serotype 2 virus isolate BR DEN2 01-01. In the primary siRNA screening of 779 kinase-related genes, knockdown of 22 genes showed a reduction in DENV-2 infection. Conversely, knockdown of 8 genes enhanced viral infection. To assess host cell specificity, the confi...
Source: Antiviral Research - July 18, 2014 Category: Virology Authors: Kwon YJ, Heo J, Wong HE, Cruz DJ, Velumani S, da Silva CT, Mosimann AL, Duarte Dos Santos CN, Freitas-Junior LH, Fink K Tags: Antiviral Res Source Type: research

Role of semaphorin‐1a in the developing visual system of the disease vector mosquito Aedes aegypti
Conclusions: The results of this investigation indicate that Sem1 is required for optic lobe development in A. aegypti and highlight the behavioral importance of a functioning visual system in pre‐adult mosquitoes. Developmental Dynamics, 2014. © 2014 Wiley Periodicals, Inc.
Source: Developmental Dynamics - July 1, 2014 Category: Molecular Biology Authors: Keshava Mysore, Ellen Flannery, Matthew T. Leming, Michael Tomchaney, Lucy Shi, Longhua Sun, Joseph E. O’Tousa, David W. Severson, Molly Duman‐Scheel Tags: Patterns & Phenotypes Source Type: research

Chitosan/siRNA nanoparticle targeting demonstrates a requirement for single-minded during larval and pupal olfactory system development of the vector mosquito Aedes aegypti
Conclusions: The results of this investigation indicate that Sim has multiple functions during larval and pupal olfactory system development in A. aegypti.
Source: BMC Developmental Biology - Latest articles - February 19, 2014 Category: Zoology Authors: Keshava MysoreEmily AndrewsPing LiMolly Duman-Scheel Source Type: research

Dengue Virus NS5 Nuclear Localization Cell Biology
In this study, we examined the nuclear localization of NS5 for all four DENV serotypes. We demonstrate for the first time that there are serotypic differences in NS5 nuclear localization. Whereas the DENV-2 and -3 proteins accumulate in the nucleus, DENV-1 and -4 NS5 are predominantly if not exclusively localized to the cytoplasm. Comparative studies on the DENV-2 and -4 NS5 proteins revealed that the difference in DENV-4 NS5 nuclear localization was not due to rapid nuclear export but rather the lack of a functional nuclear localization sequence. Interaction studies using DENV-2 and -4 NS5 and human importin-α isoforms f...
Source: Journal of Biological Chemistry - August 2, 2013 Category: Chemistry Authors: Hannemann, H., Sung, P.-Y., Chiu, H.-C., Yousuf, A., Bird, J., Lim, S. P., Davidson, A. D. Tags: Microbiology Source Type: research

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