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Inhibition of cGAS aggravated the host inflammatory response to < em > Aspergillus fumigatus < /em >
Conclusion: Based on our analysis, we conclude that activating cGAS might increase host resistance to A. fumigatus, protect against pulmonary illnesses brought on by A. fumigatus and that exploring the cGAS-STING signaling pathway is beneficial not only for the immunological investigation of IPA but also may be a potential therapeutic objective.PMID:37190937 | DOI:10.1080/01902148.2023.2211663
Source: Experimental Lung Research - May 16, 2023 Category: Respiratory Medicine Authors: Mei Peng Xiujun Li Xiaobing Zhang Li Peng Source Type: research

NLRP3 inflammasome is activated via phosphoinositide 3-kinase {delta} pathway in Aspergillus fumigatus-induced allergic airway inflammation
In this study, we focused on an association of NLRP3 inflammasome activation with PI3K- signaling in Aspergillus fumigatus (Af)-induced allergic lung inflammation. Using Af-exposed in vivo and in vitro experimental systems, we have investigated the role of PI3K- in the regulation of NLRP3 inflammasome activation in the pathogenesis of fungus-induced allergic lung inflammation.The protein expression of NLRP3, caspase-1, and IL-1bin lungs was significantly increased after the challenge in Af-sensitized and -challenged mice. Protein expression of NLRP3 and caspase-1 was also remarkably elevated in Af-stimulated cultured trach...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Lee, Y. C., Kim, S. R., Lee, K. B., Park, H. J., Jeong, J. S. Tags: 5.3 Allergy and Immunology Source Type: research

Phosphoinositide 3-kinase {delta} signaling modulates endoplasmic reticulum stress in aspergillus fumigatus-induced allergic lung inflammation
In this study, we aimed to elucidate an association of ER stress with PI3K- signaling in fungus-induced allergic lung inflammation.Using Aspergillus fumigatus-exposed in vivo and in vitro experimental systems, we have investigated the role of PI3K- in the regulation of ER stress in the pathogenesis of allergic lung inflammation.The Aspergillus fumigatus-sensitized and -challenged mice showed that the expression of ER stress markers and the protein levels of unfolded protein response (UPR)-related markers in lung tissues were significantly increased after Aspergillus fumigatus challenge. Protein expression of ER stress mark...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lee, Y. C., Kim, S. R., Lee, K. S., Ko, Y. H., Jeong, J. S. Tags: 5.3 Allergy and Immunology Source Type: research