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Infectious Disease: Aspergillus
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Total 48 results found since Jan 2013.
Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis
CONCLUSION: DMF limits fungal growth by suppressing biofilm formation, conidial adherence and respiratory metabolism. It also exerts an anti-inflammatory effect on fungal keratitis by inhibiting pyroptosis, which could be regulated by Nrf2. Our results suggest that DMF plays a therapeutic role in fungal keratitis.PMID:36641891 | DOI:10.1016/j.intimp.2023.109721
Source: International Immunopharmacology - January 15, 2023 Category: Allergy & Immunology Authors: Lingwen Gu Jing Lin Qian Wang Lina Zhang Min Yin Hao Lin Hengrui Zheng Guiqiu Zhao Cui Li Source Type: research
Honokiol reduces fungal burden and ameliorate inflammation lesions of Aspergillus fumigatus keratitis via Dectin-2 down-regulation
CONCLUSIONS: Honokiol possesses anti-fungal and anti-inflammatory effects in Aspergillus fumigatus keratitis and may develop a potential and safe therapeutic modality for FK.PMID:36933490 | DOI:10.1016/j.intimp.2023.109849
Source: International Immunopharmacology - March 18, 2023 Category: Allergy & Immunology Authors: Lu Zhan Xue Tian Jing Lin Yingxue Zhang Hengrui Zheng Xudong Peng Guiqiu Zhao Source Type: research
Inhibition of cGAS aggravated the host inflammatory response to < em > Aspergillus fumigatus < /em >
Conclusion: Based on our analysis, we conclude that activating cGAS might increase host resistance to A. fumigatus, protect against pulmonary illnesses brought on by A. fumigatus and that exploring the cGAS-STING signaling pathway is beneficial not only for the immunological investigation of IPA but also may be a potential therapeutic objective.PMID:37190937 | DOI:10.1080/01902148.2023.2211663
Source: Experimental Lung Research - May 16, 2023 Category: Respiratory Medicine Authors: Mei Peng Xiujun Li Xiaobing Zhang Li Peng Source Type: research
