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Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3
In conclusion, our study demonstrates that NBCe1 regulates acid extrusion in prostate cancer cells and inhibiting or abolishing this transporter decreases cancer cell proliferation.PMID:34013380 | DOI:10.3892/or.2021.8080
Source: Oncology Reports - May 20, 2021 Category: Cancer & Oncology Authors: Jun Ming Li Soojung Lee Reda Zafar Eunjung Shin Inyeong Choi Source Type: research

Long non ‑coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11.
Long non‑coding RNA BCYRN1 promotes prostate cancer progression via elevation of HDAC11. Oncol Rep. 2020 Sep;44(3):1233-1245 Authors: Huo W, Qi F, Wang K Abstract Prostate cancer is a serious threat to men's health worldwide. While previous studies have demonstrated that long non‑coding RNAs (lncRNAs) are closely associated with the initiation and development of several types of cancer, the role of lncRNAs in the progression of prostate cancer remains incompletely understood. In the present study, the lncRNA brain cytoplasmic RNA 1 (BCYRN1) was found to be overexpressed in prostate tumors compared ...
Source: Oncology Reports - July 28, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

E2F7, regulated by miR ‑30c, inhibits apoptosis and promotes cell cycle of prostate cancer cells.
In conclusion, the present study suggested that E2F7 may be positively associated with PCa cell proliferation by inhibiting p21, whereas E2F7 is in turn under regulation by miR‑30c. These observations suggest the miR‑30c/E2F7/p21 axis to be a viable therapeutic target for PCa. PMID: 32582990 [PubMed - as supplied by publisher]
Source: Oncology Reports - June 27, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cholinergic α5 nicotinic receptor is involved in the proliferation and invasion of human prostate cancer cells.
Authors: Qi JC, Xue WY, Zhang YP, Qu CB, Lu BS, Yin YW, Liu KL, Wang DB, Li W, Zhao ZM Abstract Nicotinic acetylcholine receptor (nAChR) subunit α5 (α5‑nAChR) is involved in tumor cell proliferation, inhibition of apoptosis, progression of metastasis, and induction of angiogenesis in certain solid tumors. However, the role of α5‑nAChR in prostate cancer cell growth and metastasis is unclear. In the present study, the role of α5‑nAChR in cell proliferation, migration, invasion and apoptosis was investigated by silencing the expression levels of α5‑nAChR in the prostate cancer cell lines DU145 and PC3. ...
Source: Oncology Reports - December 5, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Androgen receptor induces EPHA3 expression by interacting with transcription factor SP1.
This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively. The EPHA3 mRNA and protein levels were both found to be elevated by dihydrotestosterone (DHT) hormone in a dose‑ and time‑dependent manner, as AR and prostate‑specific antigen (PSA) expression were increased. Similarly, EPHA3 protein levels were also increased in the PCa cel...
Source: Oncology Reports - June 22, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PARP1-siRNA suppresses human prostate cancer cell growth and progression.
Authors: Lai Y, Kong Z, Zeng T, Xu S, Duan X, Li S, Cai C, Zhao Z, Wu W Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors, such as olaparib or rucaparib, have shown treatment efficacy in BRCA1/2-deficient tumors. However, since PARP inhibitors (PARPi) mainly modulate the activation of PARP but not its expression, whether small interfering RNA (siRNA) specific to PARP has the same function as PARPi has not been well defined. In the present study it was demonstrated that PARP1-siRNA could reduce prostate cancer (PCa) cell progression regardless of the BRCA1/2 mutation. PARP1 silencing could significantly inhibi...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Silencing of vacuolar ATPase c  subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner. Oncol Rep. 2017 Nov 10;: Authors: Zou P, Yang Y, Xu X, Liu B, Mei F, You J, Liu Q, Pei F Abstract Vacuolar ATPase (V-ATPase), widespread in eukaryotic cells, is extensively expressed in many highly metastatic tumors, of which the V-ATPase c subunit ATP6V0C is particularly associated with the invasion and metastasis of cancer. ATP6V0C was directly found to interact with LASS2/TMSG1 which is a new tumor metastasis inhibitory gene identified by our laboratory in 1999. I...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer.
Authors: Yang L, Zha TQ, He X, Chen L, Zhu Q, Wu WB, Nie FQ, Wang Q, Zang CS, Zhang ML, He J, Li W, Jiang W, Lu KH Abstract Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small cell...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CtBP2 is associated with angiogenesis and regulates the apoptosis of prostate cancer cells.
Authors: Xuan Q, Zhong X, Li W, Mo Z, Huang Y, Hu Y Abstract Angiogenesis is associated with prostate cancer (PCa) development and progression. Aberrant expression of C-terminal binding protein (CtBP)2 has been observed in PCa, but whether its change in expression plays a significant role in angiogenesis has not been completely characterized. we attempted to integrate and analyze the genome-wide association study (GWAS) of follicle stimulating hormone receptor (FSHR) and CtBP2, the Cancer Genome Atlas (TCGA) data and CtBP2 binding data in CistromeMap (18) to explore the mechanism of CtBP2 in PCa, and performed pat...
Source: Oncology Reports - July 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Stanniocalcin 1 promotes cell proliferation via cyclin  E1/cyclin‑dependent kinase 2 in human prostate carcinoma.
Stanniocalcin 1 promotes cell proliferation via cyclin E1/cyclin‑dependent kinase 2 in human prostate carcinoma. Oncol Rep. 2017 Mar 13;: Authors: Bai Y, Xiao Y, Dai Y, Chen X, Li D, Tan X, Zhang X Abstract Stanniocalcin 1 (STC1) is a glycoprotein hormone that is involved in calcium/phosphate homeostasis. Increasing evidence suggests that STC1 is involved in carcinogenesis; however, few studies have defined the mechanisms and functional roles of STC1 activity in prostate carcinogenesis. In the present study, MTT, flow cytometry and colony formation assays, and small interfering RNA (siRNA) and overe...
Source: Oncology Reports - March 31, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2.
Authors: Zhang H, Du X, Sun TT, Wang CL, Li Y, Wu SZ Abstract Prostatic carcinoma is the most aggressive tumor in adult men. Warburg effect is an important characteristic of tumor cell metabolism including prostate cancer cells, in which hexokinase 2 (HK2), a major rate-limiting enzyme involved in Warburg effect, is selectively upregulated. The lectin PCL is a mannose binding lectin which induces tumor cell apoptosis and autophagy. In the present study, we report that PCL could lower glucose consumption and lactate production, shift the Warburg effect by inhibiting the expression of HK2 in PC3 cells and the suppres...
Source: Oncology Reports - January 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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