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Differential effects of < i > WRAP53 < /i > transcript variants on non-small cell lung cancer cell behaviors
ConclusionsWRAP53 transcript variants exerted different functions in non-small cell lung cancer cells and regulated non-small cell lung cancer cell behaviors depending on the p53 expression.
Source: PLoS One - January 27, 2023 Category: Biomedical Science Authors: Yan Zhu Source Type: research

The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells
by Xin Yao, Tri Pham, Brandi Temple, Selena Gray, Cornita Cannon, Renwei Chen, Asim B. Abdel-Mageed, Hector Biliran The mitochondrial Bcl-2 inhibitor of transcription 1 (Bit1) protein is part of an anoikis-regulating pathway that is selectively dependent on integrins. We previously demonstrated that the caspase-independent apoptotic effector Bit1 exerts tumor suppressive function in lung cancer in part by inhib iting anoikis resistance and anchorage-independent growthin vitro and tumorigenicityin vivo. Herein we show a novel function of Bit1 as an inhibitor cell migration and epithelial –mesenchymal transition (EMT) in ...
Source: PLoS One - September 20, 2016 Category: Biomedical Science Authors: Xin Yao Source Type: research

TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers
by Katharina Leithner, Birgit Hirschmugl, Yingji Li, Bi Tang, Rita Papp, Chandran Nagaraj, Elvira Stacher, Philipp Stiegler, Jörg Lindenmann, Andrea Olschewski, Horst Olschewski, Andelko Hrzenjak Lung cancer is the leading cause of cancer deaths worldwide; survival times are poor despite therapy. The role of the two-pore domain K+ (K2P) channel TASK-1 (KCNK3) in lung cancer is at present unknown. We found that TASK-1 is expressed in non-small cell lung cancer (NSCLC) cell lines at variable levels. In a highly TASK-1 expressing NSCLC cell line, A549, a characteristic pH- and hypoxia-sensitive non-inactivating K+ current w...
Source: PLoS One - June 12, 2016 Category: Biomedical Science Authors: Katharina Leithner Source Type: research

IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis
Conclusions IL-24 disrupts the SDF-1/CXCR4 signaling pathway and inhibits lung tumor cell migration and invasion. Additionally, IL-24, when combined with CXCR4 inhibitors exhibited enhanced anti-metastatic activity and is an attractive therapeutic strategy for lung metastasis.
Source: PLoS One - March 16, 2015 Category: Biomedical Science Authors: Janani Panneerselvam et al. Source Type: research