IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis

Conclusions IL-24 disrupts the SDF-1/CXCR4 signaling pathway and inhibits lung tumor cell migration and invasion. Additionally, IL-24, when combined with CXCR4 inhibitors exhibited enhanced anti-metastatic activity and is an attractive therapeutic strategy for lung metastasis.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0122439

Source: PLoS One - March 16, 2015 Category: Biomedical Science Authors: Janani Panneerselvam et al. Source Type: research