• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum
In this study the receptor specific uptake of folic acid-functionalized iron oxide nanoparticles was determined in ovarian cancer cells. It was found that the presence of serum proteins is an absolute requirement for the uptake of these nanoparticles. The described strategy for receptor-mediated uptake of nanoparticles with pre-defined surface chemistry may enable a better targeting of nanoparticles for additional therapeutic and imaging applications. Graphical abstract
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 10, 2014 Category: Nanotechnology Source Type: research

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression
This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based nanoplatforms for cancer-targeted delivery of near-infrared photosensitizer, phthalocyanine, and DJ-1 siRNA have been constructed. In vitro studies revealed that therapeutic efficacy of the combinatorial approach was enhanced when compared to PDT alone and this enhancement was more pronounced in o...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 2, 2015 Category: Nanotechnology Source Type: research

Quantum dots-hemin: Preparation and application in the absorption of heme iron
Publication date: October 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine, Volume 12, Issue 7 Author(s): Lina Geng, Xianglin Duan, Yan Wang, Yashuo Zhao, Guofen Gao, Delong Liu, Yan-Zhong Chang, Peng Yu The absorption mechanism of heme iron remains unclear due to the limit of labeling techniques. Quantum dots (QDs) are powerful fluorescent probes resistant to photobleaching, however, there is no data about the application of QDs in heme iron absorption. Herein, we prepared hemin-coated CdSe/ZnS (QDs-hemin), and studied their absorption in vitro and in vivo. Results showed that QDs-hemin had uniform...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 9, 2016 Category: Nanotechnology Source Type: research

A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin
Publication date: Available online 19 October 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Phei Er Saw, Jinho Park, Sangyong Jon, Omid C. Farokhzad A major problem with cancer chemotherapy begins when cells acquire resistance. Drug-resistant cancer cells typically upregulate multi-drug resistance proteins such as P-glycoprotein (P-gp). However, the lack of overexpressed surface biomarkers has limited the targeted therapy of drug-resistant cancers. Here we report a drug-delivery carrier decorated with a targeting ligand for a surface marker protein Extra-domain B(EDB) specific to drug-resistant...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 28, 2016 Category: Nanotechnology Source Type: research

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA
Publication date: Available online 28 December 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Jayesh A. Kulkarni, J. Layne Myhre, Sam Chen, Yuen Yi C. Tam, Adrian Danescu, Joy M. Richman, Pieter R. Cullis Lipid nanoparticles (LNPs) containing distearolyphosphatidlycholine (DSPC), and ionizable amino-lipids such as (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. Here we explore the utility of similar LNP systems as transfection reagents for plasmid DNA (pDNA). It is shown that replacement of DSPC by unsat...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - December 27, 2016 Category: Nanotechnology Source Type: research

Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
Publication date: Available online 11 June 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Forrest M. Kievit, Kui Wang, Tatsuya Ozawa, Aria W. Tarudji, John R. Silber, Eric C. Holland, Richard G. Ellenbogen, Miqin Zhang Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo therapies. Therefore, strategies that enhance the effects of these therapies should provide significant benefits to GBM patients. We have developed a nanoparticle delivery vehicle that can stably bind and protect nucleic acids for specific delivery into brain tumo...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 11, 2017 Category: Nanotechnology Source Type: research

Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis
This report describes the development of polyplexes based on CXCR4-inhibiting poly(ethylenimine) derivative (PEI-C) for pulmonary delivery of siRNA to silence plasminogen activator inhibitor-1 (siPAI-1) as a new combination treatment of pulmonary fibrosis (PF). Safety and delivery efficacy of the PEI-C/siPAI-1 polyplexes was investigated in vitro in primary lung fibroblasts isolated from mice with bleomycin-induced PF. Biodistribution analysis following intratracheal administration of fluorescently labeled polyplexes showed prolonged retention in the lungs. Treatment of mice with bleomycin-induced PF using the PEI-C/siPAI-...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 16, 2018 Category: Nanotechnology Source Type: research

High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment
Publication date: Available online 20 September 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Chengyong He, Shengwei Jiang, Huan Yao, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin, Yuchun Lin, Xiaoyuan ChenAbstractMitophagy, a selective autophagy of mitochondria, clears up damaged mitochondria to maintain cell homeostasis. We performed high-content analysis (HCA) to detect the increase of PINK1, an essential protein controlling mitophagy, in hepatic cells treated with several nanoparticles (NPs). PINK1 immunofluorescence-based HCA was more sensitive th...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 21, 2018 Category: Nanotechnology Source Type: research

Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors.
This study outlines the fabrication of a lipoplex of SOX2 small interfering RNA (CL-siSOX2) for targeted treatment of SOX2-enriched, CSC-derived orthotopic and xenograft lung tumors in CB-17 SCID mice. CL-siSOX2 induced tumor contraction in Cisplatin-naïve and Cisplatin-treated groups by 85% and 94% respectively. Reduction in tumor weight and volume following treatment with CL-siSOX2 was associated with reduced protein expression of SOX2 and markers of tumor initiation, inflammation, invasion and metastasis in mice tumor xenografts. And histological staining of lung tumor sections showed reduction in SOX2 expression was a...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 1, 2019 Category: Nanotechnology Source Type: research

Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuate diabetes-induced vascular remodeling and dysfunction
This study showed chronic in vivo administration of PAMAM dendrimers in an animal model of diabetes inhibited EGFR-ERK1/2-ROCK signaling and improved diabetes-induced vascular remodeling and dysfunction in a dose, generation (G6 > G5) and surface chemistry-dependent manner (cationic> anionic> neutral). Thus, naked PAMAM dendrimers have the propensity to modulate key (e.g. EGFR) cell signaling cascades with associated pharmacological consequences in vivo that are dependent on their physicochemical properties. PAMAMs, alone or in combination with vasculoprotective agents, might therefore have a beneficial role in t...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 5, 2019 Category: Nanotechnology Source Type: research

Cationic lipoplexes for treatment of cancer stem cell-derived murine lung tumors
This study outlines the fabrication of a lipoplex of SOX2 small interfering RNA (CL-siSOX2) for targeted treatment of SOX2-enriched, CSC-derived orthotopic and xenograft lung tumors in CB-17 SCID mice. CL-siSOX2 induced tumor contraction in cisplatin-naïve and cisplatin-treated groups by 85% and 94% respectively. Reduction in tumor weight and volume following treatment with CL-siSOX2 was associated with reduced protein expression of SOX2 and markers of tumor initiation, inflammation, invasion and metastasis in mice tumor xenografts. In addition, histological staining of lung tumor sections showed reduction in SOX2 express...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 20, 2019 Category: Nanotechnology Source Type: research

Sirtuin 6 mediated stem cell Cardiomyogenesis on protein coated Nanofibrous scaffolds
This study, thus, demonstrates that protein coated scaffolds can augment cardiomyogenic differentiation of stem cells through a combination of topographical and biomolecular signals.Graphical AbstractCollagen coated polymer nanofibers promote stem cell cardiomyogenesis through Sirtuin6-mediated Wnt signaling pathway.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 27, 2019 Category: Nanotechnology Source Type: research

Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: Formulation and in-vivo efficacy evaluation
Publication date: Available online 10 March 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Farkhondeh Chaharband, Narsis Daftarian, Mozhgan Rezaei Kanavi, Reyhaneh Varshochian, Maliheh Hajiramezanali, Parisa Norouzi, Ehsan Arefian, Fatemeh Atyabi, Rassoul Dinarvand
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 11, 2020 Category: Nanotechnology Source Type: research

siRNA and chemotherapeutic molecules entrapped into a redox-responsive platform for targeted synergistic combination therapy of glioma
Publication date: Available online 13 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Lijuan Wen, Changlong Wen, Fengtian Zhang, Kai Wang, Hong Yuan, Fuqiang Hu
Source: Nanomedicine: Nanotechnology, Biology and Medicine - May 14, 2020 Category: Nanotechnology Source Type: research

siRNA based drug design, quality, delivery and clinical translation
Publication date: Available online 13 June 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Md Abdus Subhan, VP Torchilin
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 15, 2020 Category: Nanotechnology Source Type: research

Pages: 1  2  3  4  5