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Total 39 results found since Jan 2013.
Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
Publication date: 10 December 2019Source: Cell Reports, Volume 29, Issue 11Author(s): Jiagui Song, Tianzhuo Wang, Xiaochun Chi, Xiaofan Wei, Sidi Xu, Miao Yu, Huiying He, Ji Ma, Xueying Li, Juan Du, Xiaoran Sun, Yunling Wang, Jun Zhan, Hongquan ZhangSummaryThe Hippo signaling pathway plays a key role in development and cancer progression. However, molecules that intrinsically inhibit this pathway are less well known. Here, we report that the focal adhesion molecule Kindlin-2 inhibits Hippo signaling by interacting with and degrading MOB1 and promoting the interaction between MOB1 and the E3 ligase praja2. Kindlin-2 thus in...
Source: Cell Reports - December 11, 2019 Category: Cytology Source Type: research
Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis
Publication date: 13 August 2019Source: Cell Reports, Volume 28, Issue 7Author(s): Hila Doron, Malak Amer, Nour Ershaid, Raquel Blazquez, Ophir Shani, Tzlil Gener Lahav, Noam Cohen, Omer Adler, Zahi Hakim, Sabina Pozzi, Anna Scomparin, Jonathan Cohen, Muhammad Yassin, Lea Monteran, Rachel Grossman, Galia Tsarfaty, Chen Luxenburg, Ronit Satchi-Fainaro, Tobias Pukrop, Neta ErezSummaryMelanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance. We used a mouse model of spont...
Source: Cell Reports - August 14, 2019 Category: Cytology Source Type: research
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
Publication date: 25 June 2019Source: Cell Reports, Volume 27, Issue 13Author(s): Michela Borghesan, Juan Fafián-Labora, Olga Eleftheriadou, Paula Carpintero-Fernández, Marta Paez-Ribes, Gema Vizcay-Barrena, Avital Swisa, Dror Kolodkin-Gal, Pilar Ximénez-Embún, Robert Lowe, Belen Martín-Martín, Hector Peinado, Javier Muñoz, Roland A. Fleck, Yuval Dor, Ittai Ben-Porath, Anna Vossenkamper, Daniel Muñoz-Espin, Ana O’LoghlenSummarySenescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (...
Source: Cell Reports - June 26, 2019 Category: Cytology Source Type: research
Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus
Publication date: 14 May 2019Source: Cell Reports, Volume 27, Issue 7Author(s): Benedetta Assetta, Jenna Morris-Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara, Melissa S. Maginnis, Sheila A. Haley, Walter J. AtwoodSummaryJC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML). The entry receptors for JCPyV belong to the 5-hydroxytryptamine 2 receptor (5-HT2R) family, but how individual members of the family function to facilitate infection is not known. We used proximity ligation assay (PLA) to determine that JCPyV interacts with each of the 5-HT2...
Source: Cell Reports - May 15, 2019 Category: Cytology Source Type: research
Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism
Publication date: 12 March 2019Source: Cell Reports, Volume 26, Issue 11Author(s): Devesh Mishra, Jennifer E. Richard, Ivana Maric, Begona Porteiro, Martin Häring, Sander Kooijman, Saliha Musovic, Kim Eerola, Lorena López-Ferreras, Eduard Peris, Katarzyna Grycel, Olesya T. Shevchouk, Peter Micallef, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm, Harvey J. Grill, Ruben Nogueiras, Karolina P. SkibickaSummaryChronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. H...
Source: Cell Reports - March 14, 2019 Category: Cytology Source Type: research
A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells
This study identifies Wolbachia-mediated downregulation of insulin receptor kinase activity as a mechanism contributing to the blocking of super-infection by arboviruses.Graphical Abstract
Source: Cell Reports - January 16, 2019 Category: Cytology Source Type: research
IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes
Publication date: 11 December 2018Source: Cell Reports, Volume 25, Issue 11Author(s): Peace Atakpa, Nagendra Babu Thillaiappan, Stefania Mataragka, David L. Prole, Colin W. TaylorSummaryInositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) allow extracellular stimuli to redistribute Ca2+ from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H+-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca2+ released by all IP3R subtypes, but not Ca2+ entering cells through store-operated Ca2+ entry (SOCE). A low-affinity Ca2+ sensor targeted to lysosomal membranes reports large, l...
Source: Cell Reports - December 12, 2018 Category: Cytology Source Type: research
C. elegans Heterochromatin Factor SET-32 Plays an Essential Role in Transgenerational Establishment of Nuclear RNAi-Mediated Epigenetic Silencing
Publication date: 20 November 2018Source: Cell Reports, Volume 25, Issue 8Author(s): Natallia Kalinava, Julie Zhouli Ni, Zoran Gajic, Matthew Kim, Helen Ushakov, Sam Guoping GuSummaryThe dynamic process by which nuclear RNAi engages a transcriptionally active target, before the repressive state is stably established, remains largely a mystery. Here, we found that the onset of exogenous dsRNA-induced nuclear RNAi in C. elegans is a transgenerational process, and it requires a putative histone methyltransferase (HMT), SET-32. By developing a CRISPR-based genetic approach, we found that silencing establishment at the endoge...
Source: Cell Reports - November 21, 2018 Category: Cytology Source Type: research
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Daniel S.J. Miller, Robert D. Bloxham, Ming Jiang, Ilaria Gori, Rebecca E. Saunders, Debipriya Das, Probir Chakravarty, Michael Howell, Caroline S. HillSummarySignal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating appropriate cellular responses, with perturbations in this process contributing to human diseases, including cancer. For receptors recognizing ligands of...
Source: Cell Reports - November 14, 2018 Category: Cytology Source Type: research
Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP
Publication date: 6 November 2018Source: Cell Reports, Volume 25, Issue 6Author(s): Roberto Moreno-Vicente, Dácil María Pavón, Inés Martín-Padura, Mauro Català-Montoro, Alberto Díez-Sánchez, Antonio Quílez-Álvarez, Juan Antonio López, Miguel Sánchez-Álvarez, Jesús Vázquez, Raffaele Strippoli, Miguel A. del PozoSummaryThe transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 posi...
Source: Cell Reports - November 7, 2018 Category: Cytology Source Type: research
Splicing and Chromatin Factors Jointly Regulate Epidermal Differentiation
Publication date: 30 October 2018Source: Cell Reports, Volume 25, Issue 5Author(s): Sabine E.J. Tanis, Pascal W.T.C. Jansen, Huiqing Zhou, Simon J. van Heeringen, Michiel Vermeulen, Markus Kretz, Klaas W. MulderSummaryEpidermal homeostasis requires balanced progenitor cell proliferation and loss of differentiated cells from the epidermal surface. During this process, cells undergo major changes in their transcriptional programs to accommodate new cellular functions. We found that transcriptional and post-transcriptional mechanisms underlying these changes jointly control genes involved in cell adhesion, a key process in e...
Source: Cell Reports - November 1, 2018 Category: Cytology Source Type: research
IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human Macrophages
Publication date: 2 October 2018Source: Cell Reports, Volume 25, Issue 1Author(s): Sinu P. John, Jing Sun, Rebecca J. Carlson, Binh Cao, Clinton J. Bradfield, Jian Song, Margery Smelkinson, Iain D.C. FraserSummaryActivation of the TLR4 signaling pathway by lipopolysaccharide (LPS) leads to induction of both inflammatory and interferon-stimulated genes, but the mechanisms through which these coordinately activated transcriptional programs are balanced to promote an optimal innate immune response remain poorly understood. In a genome-wide small interfering RNA (siRNA) screen of the LPS-induced tumor necrosis factor α (TNF-...
Source: Cell Reports - October 4, 2018 Category: Cytology Source Type: research
FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells
Publication date: 31 July 2018Source: Cell Reports, Volume 24, Issue 5Author(s): Allison B. Herman, Christine N. Vrakas, Mitali Ray, Sheri E. Kelemen, Michael J. Sweredoski, Annie Moradian, Dale S. Haines, Michael V. AutieriSummaryThis work identifies the fragile-X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMCs). FXR1 was identified as an HuR-interacting protein by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The HuR-FXR1 interaction is abrogated in RNase-treated extracts, indicating that their association is tethered by mRNAs. FXR1 expression...
Source: Cell Reports - August 1, 2018 Category: Cytology Source Type: research
ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. QuezadaSummaryThe immunosuppressive transmembrane protein PD-L1 was shown to traffic via the multivesicular body (MVB) and to be released on exosomes. A high-content siRNA screen identified the endosomal sorting co...
Source: Cell Reports - July 18, 2018 Category: Cytology Source Type: research
ULK1 Phosphorylates and Regulates Mineralocorticoid Receptor
Publication date: 17 July 2018Source: Cell Reports, Volume 24, Issue 3Author(s): Shigeru Shibata, Kenichi Ishizawa, Qin Wang, Ning Xu, Toshiro Fujita, Shunya Uchida, Richard P. LiftonSummaryMineralocorticoid receptor (MR) signaling regulates both renal Na-Cl reabsorption and K+ excretion. We previously demonstrated that phosphorylation of S843 in the MR ligand-binding domain in renal intercalated cells is involved in the balance of these activities by regulating ligand binding and signaling. However, the kinase that phosphorylates MRS843 is unknown. Using a high-throughput screen assay of 197 kinases, we found that ULK1 i...
Source: Cell Reports - July 18, 2018 Category: Cytology Source Type: research
