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Source: Cell Reports
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Total 39 results found since Jan 2013.
A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress
Publication date: 13 March 2018 Source:Cell Reports, Volume 22, Issue 11 Author(s): Kengo Watanabe, Tsuyoshi Umeda, Kuniyoshi Niwa, Isao Naguro, Hidenori Ichijo Cell volume regulation is a vital system for cellular activities. When perturbed by hypoosmotic or hyperosmotic stress, cells immediately induce the cell volume recovery system, regulatory volume decrease (RVD) or regulatory volume increase (RVI), respectively. In contrast to the knowledge about effector molecules, the molecular mechanisms linking osmosensing to RVD/RVI induction remain unknown. Additionally, few reciprocal responders in the bidirectional osmotic ...
Source: Cell Reports - March 14, 2018 Category: Cytology Source Type: research
S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking
Publication date: 27 February 2018 Source:Cell Reports, Volume 22, Issue 9 Author(s): Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover, Bret R. Sellman Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due to a reduction in inf...
Source: Cell Reports - February 27, 2018 Category: Cytology Source Type: research
Differential Effector Engagement by Oncogenic KRAS
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Tina L. Yuan, Arnaud Amzallag, Rachel Bagni, Ming Yi, Shervin Afghani, William Burgan, Nicole Fer, Leslie A. Strathern, Katie Powell, Brian Smith, Andrew M. Waters, David Drubin, Ty Thomson, Rosy Liao, Patricia Greninger, Giovanna T. Stein, Ellen Murchie, Eliane Cortez, Regina K. Egan, Lauren Procter, Matthew Bess, Kwong Tai Cheng, Chih-Shia Lee, Liam Changwoo Lee, Christof Fellmann, Robert Stephens, Ji Luo, Scott W. Lowe, Cyril H. Benes, Frank McCormick KRAS can bind numerous effector proteins, which activate different downstream signal...
Source: Cell Reports - February 24, 2018 Category: Cytology Source Type: research
Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Katherine I. Farley-Barnes, Kathleen L. McCann, Lisa M. Ogawa, Janie Merkel, Yulia V. Surovtseva, Susan J. Baserga Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in yeast have established some of the biological principles of ribosome biogenesis, many of the intricacies of its regulation in higher eukaryotes remain unknown. To understand how ribosome biogenesis is globally integrated in human cells, we conducted a genome-wide siRNA screen for regulators of nucleolar number. We found 139 proteins wh...
Source: Cell Reports - February 24, 2018 Category: Cytology Source Type: research
The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling
In this study, we identified a key role for the membrane-bending host protein Reticulon 3.1 (RTN3.1A) during the replication cycle of three flaviviruses: West Nile virus (WNV), Dengue virus (DENV), and Zika virus (ZIKV). We observed that, during infection, RTN3.1A is redistributed and recruited to the viral replication complex, a recruitment facilitated via the WNV NS4A protein, however, not DENV or ZIKV NS4A. Critically, small interfering RNA (siRNA)-mediated knockdown of RTN3.1A expression attenuated WNV, DENV, and ZIKV replication and severely affected the stability and abundance of the NS4A protein, coinciding with a s...
Source: Cell Reports - November 7, 2017 Category: Cytology Source Type: research
Functional Dissection of the Pol V Largest Subunit CTD in RNA-Directed DNA Methylation
Publication date: 27 June 2017 Source:Cell Reports, Volume 19, Issue 13 Author(s): Jered M. Wendte, Jeremy R. Haag, Jasleen Singh, Anastasia McKinlay, Olga M. Pontes, Craig S. Pikaard Plant multisubunit RNA polymerase V (Pol V) transcription recruits Argonaute-small interfering RNA (siRNA) complexes that specify sites of RNA-directed DNA methylation (RdDM) for gene silencing. Pol V’s largest subunit, NRPE1, evolved from the largest subunit of Pol II but has a distinctive C-terminal domain (CTD). We show that the Pol V CTD is dispensable for catalytic activity in vitro yet essential in vivo. One CTD subdomain (DeCL) is...
Source: Cell Reports - June 28, 2017 Category: Cytology Source Type: research
The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly
Publication date: 20 June 2017 Source:Cell Reports, Volume 19, Issue 12 Author(s): An-Yun Chang, Stephane E. Castel, Evan Ernst, Hyun Soo Kim, Robert A. Martienssen RNAi factors and their catalytic activities are essential for heterochromatin assembly in S. pombe. This has led to the idea that siRNAs can promote H3K9 methylation by recruiting the cryptic loci regulator complex (CLRC), also known as recombination in K complex (RIKC), to the nucleation site. The conserved RNA-binding protein Rct1 (AtCyp59/SIG-7) interacts with splicing factors and RNA polymerase II. Here we show that Rct1 promotes processing of pericentr...
Source: Cell Reports - June 21, 2017 Category: Cytology Source Type: research
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients
Publication date: 20 June 2017 Source:Cell Reports, Volume 19, Issue 12 Author(s): Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therapeutics. However, the mechanism by which HSP90 ATPase inhibition triggers ubiquitylation is not understood, and the E3 ubiquitin ligases involved are largely unknown. Using a siRNA screen, we have identified components of two...
Source: Cell Reports - June 21, 2017 Category: Cytology Source Type: research
Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation
Publication date: 30 May 2017 Source:Cell Reports, Volume 19, Issue 9 Author(s): Subhash K. Tripathi, Zhi Chen, Antti Larjo, Kartiek Kanduri, Kari Nousiainen, Tarmo Äijo, Isis Ricaño-Ponce, Barbara Hrdlickova, Soile Tuomela, Essi Laajala, Verna Salo, Vinod Kumar, Cisca Wijmenga, Harri Lähdesmäki, Riitta Lahesmaa The development of therapeutic strategies to combat immune-associated diseases requires the molecular mechanisms of human Th17 cell differentiation to be fully identified and understood. To investigate transcriptional control of Th17 cell differentiation, we used primary human CD4+ T cells in small interferin...
Source: Cell Reports - May 31, 2017 Category: Cytology Source Type: research
E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia
Publication date: 21 February 2017 Source:Cell Reports, Volume 18, Issue 8 Author(s): Monica Benini, Silvia Fortuni, Ivano Condò, Giulia Alfedi, Florence Malisan, Nicola Toschi, Dario Serio, Damiano Sergio Massaro, Gaetano Arcuri, Roberto Testi, Alessandra Rufini Friedreich ataxia (FRDA) is a severe genetic neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin. To date, there is no therapy to treat this condition. The amount of residual frataxin critically affects the severity of the disease; thus, attempts to restore physiological frataxin levels are considered therapeutically rele...
Source: Cell Reports - February 21, 2017 Category: Cytology Source Type: research
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers
Publication date: 1 November 2016 Source:Cell Reports, Volume 17, Issue 6 Author(s): Hiroto Hatakeyama, Sherry Y. Wu, Yasmin A. Lyons, Sunila Pradeep, Wanqin Wang, Qian Huang, Karem A. Court, Tao Liu, Song Nie, Cristian Rodriguez-Aguayo, Fangrong Shen, Yan Huang, Takeshi Hisamatsu, Takashi Mitamura, Nicholas Jennings, Jeajun Shim, Piotr L. Dorniak, Lingegowda S. Mangala, Marco Petrillo, Vladislav A. Petyuk, Athena A. Schepmoes, Anil K. Shukla, Madeline Torres-Lugo, Ju-Seog Lee, Karin D. Rodland, Anna Fagotti, Gabriel Lopez-Berestein, Chun Li, Anil K. Sood Even though hyperthermia is a promising treatment for can...
Source: Cell Reports - October 31, 2016 Category: Cytology Source Type: research
Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH
Publication date: 11 October 2016 Source:Cell Reports, Volume 17, Issue 3 Author(s): Eric L. Allen, Danielle B. Ulanet, David Pirman, Christopher E. Mahoney, John Coco, Yaguang Si, Ying Chen, Lingling Huang, Jinmin Ren, Sung Choe, Michelle F. Clasquin, Erin Artin, Zi Peng Fan, Giovanni Cianchetta, Joshua Murtie, Marion Dorsch, Shengfang Jin, Gromoslaw A. Smolen Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained challenging. Here, we conducted an siRNA screen focusing on enzymes involved in the tricarboxylic acid ...
Source: Cell Reports - October 11, 2016 Category: Cytology Source Type: research
Unique Requirement for ESCRT Factors in Flavivirus Particle Formation on the Endoplasmic Reticulum
Publication date: Available online 18 August 2016 Source:Cell Reports Author(s): Keisuke Tabata, Masaru Arimoto, Masashi Arakawa, Atsuki Nara, Kazunobu Saito, Hiroko Omori, Arisa Arai, Tomohiro Ishikawa, Eiji Konishi, Ryosuke Suzuki, Yoshiharu Matsuura, Eiji Morita Flavivirus infection induces endoplasmic reticulum (ER) membrane rearrangements to generate a compartment for replication of the viral genome and assembly of viral particles. Using quantitative mass spectrometry, we identified several ESCRT (endosomal sorting complex required for transport) proteins that are recruited to sites of virus replication on the ER. S...
Source: Cell Reports - August 18, 2016 Category: Cytology Source Type: research
TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice
Publication date: Available online 12 May 2016 Source:Cell Reports Author(s): Lee Adam Wheeler, Radiana T. Trifonova, Vladimir Vrbanac, Natasha S. Barteneva, Xing Liu, Brooke Bollman, Lauren Onofrey, Sachin Mulik, Shahin Ranjbar, Andrew D. Luster, Andrew M. Tager, Judy Lieberman Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection. HIV does not normally induce type I interferons in infected cells, but does if TREX1 is knocked down. Here, we investigated the ...
Source: Cell Reports - May 12, 2016 Category: Cytology Source Type: research
The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability
Publication date: Available online 14 April 2016 Source:Cell Reports Author(s): Teresa L.F. Ho, Guillaume Guilbaud, J. Julian Blow, Julian E. Sale, Christine J. Watson Regulation of DNA replication and cell division is essential for tissue growth and maintenance of genomic integrity and is particularly important in tissues that undergo continuous regeneration such as mammary glands. We have previously shown that disruption of the KRAB-domain zinc finger protein Roma/Zfp157 results in hyperproliferation of mammary epithelial cells (MECs) during pregnancy. Here, we delineate the mechanism by which Roma engenders th...
Source: Cell Reports - April 14, 2016 Category: Cytology Source Type: research
