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Source: Cell Reports
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Total 39 results found since Jan 2013.
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
Publication date: Available online 3 March 2016 Source:Cell Reports Author(s): James Campbell, Colm J. Ryan, Rachel Brough, Ilirjana Bajrami, Helen N. Pemberton, Irene Y. Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T. Williamson, David A. Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fenton, Rachael Natrajan, Sandra J. Strauss, Alan Ashworth, Christopher J. Lord One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell line...
Source: Cell Reports - March 4, 2016 Category: Cytology Source Type: research
Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis
Publication date: Available online 10 December 2015 Source:Cell Reports Author(s): Rajesha Rupaimoole, Jaehyuk Lee, Monika Haemmerle, Hui Ling, Rebecca A. Previs, Sunila Pradeep, Sherry Y. Wu, Cristina Ivan, Manuela Ferracin, Jennifer B. Dennison, Niki M. Zacharias Millward, Archana S. Nagaraja, Kshipra M. Gharpure, Michael McGuire, Nidhin Sam, Guillermo N. Armaiz-Pena, Nouara C. Sadaoui, Cristian Rodriguez-Aguayo, George A. Calin, Ronny I. Drapkin, Jeffery Kovacs, Gordon B. Mills, Wei Zhang, Gabriel Lopez-Berestein, Pratip K. Bhattacharya, Anil K. Sood Long noncoding RNAs (lncRNAs...
Source: Cell Reports - December 12, 2015 Category: Cytology Source Type: research
Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells
Publication date: Available online 6 December 2015 Source:Cell Reports Author(s): Katarzyna A. Makowska, Ruth E. Hughes, Kathryn J. White, Claire M. Wells, Michelle Peckham We investigated the myosin expression profile in prostate cancer cell lines and found that Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high metastatic potential. Moreover, Myo1b and Myo10 were expressed at higher levels in metastatic tumors. Using an siRNA-based approach, we found that knockdown of each myosin resulted in distinct phenotypes. Myo10 knockdown ablated filopodia and decreased 2D migration speed....
Source: Cell Reports - December 7, 2015 Category: Cytology Source Type: research
Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle
Publication date: Available online 29 October 2015 Source:Cell Reports Author(s): Anne Bigot, William J. Duddy, Zamalou G. Ouandaogo, Elisa Negroni, Virginie Mariot, Svetlana Ghimbovschi, Brennan Harmon, Aurore Wielgosik, Camille Loiseau, Joe Devaney, Julie Dumonceaux, Gillian Butler-Browne, Vincent Mouly, Stéphanie Duguez The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging. Here, using human cells and by carrying out experiments within a strictly pre-senescent divi...
Source: Cell Reports - October 31, 2015 Category: Cytology Source Type: research
Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes
Publication date: Available online 10 September 2015 Source:Cell Reports Author(s): Desy S. Lee, Jyh-Hong Chen, David J. Lundy, Chung-Hung Liu, Shiaw-Min Hwang, Lil Pabon, Ru-Chi Shieh, Chien-Chang Chen, Sheng-Nan Wu, Yu-Ting Yan, Sho-Tone Lee, Po-Min Chiang, Shu Chien, Charles E. Murry, Patrick C.H. Hsieh Pluripotent-cell-derived cardiomyocytes have great potential for use in research and medicine, but limitations in their maturity currently constrain their usefulness. Here, we report a method for improving features of maturation in murine and human embryonic-stem-cell-derived cardiomyocytes (m/hESC-C...
Source: Cell Reports - September 11, 2015 Category: Cytology Source Type: research
In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus
Publication date: Available online 11 June 2015 Source:Cell Reports Author(s): Asiel A. Benitez , Maryline Panis , Jia Xue , Andrew Varble , Jaehee V. Shim , Amy L. Frick , Carolina B. López , David Sachs , Benjamin R. tenOever Responding to an influenza A virus (IAV) infection demands an effective intrinsic cellular defense strategy to slow replication. To identify contributing host factors to this defense, we exploited the host microRNA pathway to perform an in vivo RNAi screen. To this end, IAV, lacking a functional NS1 antagonist, was engineered to encode individual siRNAs against antiviral host genes in an ef...
Source: Cell Reports - June 12, 2015 Category: Cytology Source Type: research
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression
Publication date: Available online 12 March 2015 Source:Cell Reports Author(s): Julien Fitamant , Filippos Kottakis , Samira Benhamouche , Helen S. Tian , Nicolas Chuvin , Christine A. Parachoniak , Julia M. Nagle , Rushika M. Perera , Marjorie Lapouge , Vikram Deshpande , Andrew X. Zhu , Albert Lai , Bosun Min , Yujin Hoshida , Joseph Avruch , Daniela Sia , Genís Campreciós , Andrea I. McClatchey , Josep M. Llovet , David Morrissey , Lakshmi Raj , Nabeel Bardeesy Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms...
Source: Cell Reports - March 13, 2015 Category: Cytology Source Type: research
KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum
In this study, we demonstrate that dengue virus (DENV) interacts with KDEL receptors (KDELR), which cycle between the ER and Golgi apparatus, for vesicular transport from ER to Golgi. Depletion of KDELR by siRNA reduced egress of both DENV progeny and recombinant subviral particles (RSPs). Coimmunoprecipitation of KDELR with dengue structural protein prM required three positively charged residues at the N terminus, whose mutation disrupted protein interaction and inhibited RSP transport from the ER to the Golgi. Finally, siRNA depletion of class II Arfs, which results in KDELR accumulation in the Golgi, phenocopied result...
Source: Cell Reports - March 6, 2015 Category: Cytology Source Type: research
Genome-wide RNAi Screen Reveals a Role for Multipass Membrane Proteins in Endosome-to-Golgi Retrieval
Publication date: 11 December 2014 Source:Cell Reports, Volume 9, Issue 5 Author(s): Sophia Y. Breusegem , Matthew N.J. Seaman Endosome-to-Golgi retrieval is an essential membrane trafficking pathway required for many important physiological processes and linked to neurodegenerative disease and infection by bacterial and viral pathogens. The prototypical cargo protein for this pathway is the cation-independent mannose 6-phosphate receptor (CIMPR), which delivers lysosomal hydrolases to endosomes. Efficient retrieval of CIMPR to the Golgi requires the retromer complex, but other aspects of the endosome-to-Golgi retrieva...
Source: Cell Reports - December 12, 2014 Category: Cytology Source Type: research
