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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
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Total 69 results found since Jan 2013.
Inhibition of H3K4 demethylation induces autophagy in cancer cell lines
Publication date: Available online 8 August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Zhen Wang, Qiao-Yun Long, Lin Chen, Jia-Dong Fan, Zhao-Ning Wang, Lian-Yun Li, Min Wu Epigenetic factors and related small molecules have emerged to be strongly involved in autophagy process. Here we report that 2-PCPA and GSK-LSD1, two inhibitors of histone H3K4 demethylase KDM1A/LSD1, induce autophagy in multiple mammalian cell lines. The two small molecules induce accumulation of LC3II, formation of autophagosome and autolysosome, and SQSTM1/p62 degradation. 2-PCPA treatment inhibits cell pro...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - August 8, 2017 Category: Molecular Biology Source Type: research
HPI/AMF inhibition halts the development of the aggressive phenotype of breast cancer stem cells
Publication date: Available online 23 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Juan Carlos Gallardo-Pérez, Alhelí Adán-Ladrón de Guevara, Alvaro Marín-Hernández, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez Cancer stem cells are responsible for tumor recurrence and metastasis. A new highly reproducible procedure for human breast cancer MCF-7 stem cells (BCSC) isolation and selection was developed by using a combination of hypoxia/hypoglycemia plus taxol and adriamycin for 24h. The BCSC enriched fraction (i) expressed (2–15 times) the typical stemness protein ma...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 23, 2017 Category: Molecular Biology Source Type: research
Increasing extracellular Ca2+ sensitizes TNF-alpha-induced vascular cell adhesion molecule-1 (VCAM-1) via a TRPC1/ERK1/2/NF κB-dependent pathway in human vascular endothelial cells
This study provided direct evidence that increasing extracellular Ca2+ enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFκB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process. Our studies indicate that blood calcium levels should be strictly monitored to help prevent CVD, and that TRPC1 might act as a potential target for the treatment and prevention against increased circulating calcium-enhanced CVDs.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 3, 2017 Category: Molecular Biology Source Type: research
β-Cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Xingxing Shi, Wenjing Li, Honghong Liu, Deling Yin, Jing Zhao Cardiac stem cells (CSCs) have emerged as promising cell candidates to regenerate damaged hearts, because of the potential in differentiating to cardiomyocytes. However, the differentiation is difficult to trigger without inducers. Here we reported that β-cyclodextrin (β-CD) increased the expression of cardiac transcription factors (Nkx2.5 and GATA4), structural proteins (cardiac Troponin T, cTnt), transcriptional enhancer (Mef2c...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 23, 2017 Category: Molecular Biology Source Type: research
Dehydroepiandrosterone sulfate augments blood-brain barrier and tight junction protein expression in brain endothelial cells
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Dimitrios Papadopoulos, Georgios Scheiner-Bobis Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB integrity is associated with several neuropathological disorders, treatments that augment or stabilise the BBB are scarce. Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 18, 2017 Category: Molecular Biology Source Type: research
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury
Publication date: Available online 19 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Kyung Hwan Jegal, Sang Mi Park, Sam Seok Cho, Sung Hui Byun, Sae Kwang Ku, Sang Chan Kim, Sung Hwan Ki, Il Je Cho Endoplasmic reticulum (ER) stress is characterized by an accumulation of misfolded proteins, and ER stress reduction is essential for maintaining tissue homeostasis. However, the molecular mechanisms that protect cells from ER stress are not completely understood. The present study investigated the role of sestrin 2 (SESN2) on ER stress and sought to elucidate the mechanism responsib...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 19, 2017 Category: Molecular Biology Source Type: research
Role of CCL20 mediated immune cell recruitment in NF- κB mediated TRAIL resistance of pancreatic cancer
In conclusion, our data show a functional role of a RelA-CCL20 pathway in PDAC TRAIL resistance. We demonstrate how the therapy-induced cross-talk of cancer cells with immune cells affects treatment responses, knowledge needed to tailor novel bi-specific treatments, which target tumor cell as well as immune cells. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - February 7, 2017 Category: Molecular Biology Source Type: research
Crosstalk between different family members: IL27 recapitulates IFN γ responses in HCC cells, but is inhibited by IL6-type cytokines
In this study, we show that IL27 induces STAT1 and STAT3 phosphorylation in 5 HCC lines and 3 different types of non-transformed liver cells. We were especially interested in the relevance of the IL27-induced STAT3 activation in liver cells. Thus, we compared the IL27 responses with those induced by IFNγ (STAT1-dominated response) or IL6-type cytokines (IL6, hyper-IL6 (hy-IL6) or OSM) (STAT3-dominated response) by microarray analysis and find that in HCC cells, IL27 induces an IFNγ-like, STAT1-dependent transcriptional response, but we do not find an effective STAT3-dependent response. Validation experiments corroborate ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 9, 2016 Category: Molecular Biology Source Type: research
Mechanical strain stimulates vasculogenesis and expression of angiogenesis guidance molecules of embryonic stem cells through elevation of intracellular calcium, reactive oxygen species and nitric oxide generation
Conclusions Mechanical strain stimulates vasculogenesis of ES cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 9, 2016 Category: Molecular Biology Source Type: research
Ouabain interactions with the α4 isoform of the sodium pump trigger non-classical steroid hormone signaling and integrin expression in spermatogenic cells
Publication date: Available online 4 September 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Neha Upmanyu, Raimund Dietze, Ulrike Kirch, Georgios Scheiner-Bobis In addition to the ubiquitous α1 isoform of the sodium pump, sperm cells also express a male-specific α4 isoform whose function has been associated with sperm motility, fertility, and capacitation. Here we investigate in the murine spermatogenic cell line GC-2 interactions of the α4 isoform with the cardiotonic steroid ouabain in signaling cascades involved in the non-classical action of steroid hormones. Exposure of GC-2 ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 3, 2016 Category: Molecular Biology Source Type: research
Actin related protein complex subunit 1b controls sperm release, barrier integrity and cell division during adult rat spermatogenesis
Publication date: August 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1863, Issue 8 Author(s): Anita Kumar, Kushaan Dumasia, Sharvari Deshpande, Reshma Gaonkar, N.H. Balasinor Actin remodeling is a vital process for signaling, movement and survival in all cells. In the testes, extensive actin reorganization occurs at spermatid–Sertoli cell junctions during sperm release (spermiation) and at inter Sertoli cell junctions during restructuring of the blood testis barrier (BTB). During spermiation, tubulobulbar complexes (TBCs), rich in branched actin networks, ensure recycling of s...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 20, 2016 Category: Molecular Biology Source Type: research
Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions
Publication date: July 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1863, Issue 7, Part A Author(s): Huan He, Dan Liu, Hui Lin, Shanshan Jiang, Ying Ying, Shao Chun, Haiteng Deng, Joseph Zaia, Rong Wen, Zhijun Luo Phosphatidylethanolamine binding proteins (PEBP) represent a superfamily of proteins that are conserved from bacteria to humans. In mammals, four members have been identified, PEBP1–4. To determine the functional differences among PEBP1–4 and the underlying mechanism for their actions, we performed a sequence alignment and found that PEBP4 contains a signal pep...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 6, 2016 Category: Molecular Biology Source Type: research
Syntaxin 8 is required for efficient lytic granule trafficking in cytotoxic T lymphocytes
Publication date: July 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1863, Issue 7, Part A Author(s): Shruthi S. Bhat, Kim S. Friedmann, Arne Knörck, Cora Hoxha, Petra Leidinger, Christina Backes, Eckart Meese, Andreas Keller, Jens Rettig, Markus Hoth, Bin Qu, Eva C. Schwarz Cytotoxic T lymphocytes (CTL) eliminate pathogen-infected and cancerous cells mainly by polarized secretion of lytic granules (LG, containing cytotoxic molecules like perforin and granzymes) at the immunological synapse (IS). Members of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment pr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2016 Category: Molecular Biology Source Type: research
Ganglioside GM2 mediates migration of tumor cells by interacting with integrin and modulating the downstream signaling pathway
Publication date: Available online 8 April 2016 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Manjari Kundu, Barun Mahata, Avisek Banerjee, Sohini Chakraborty, Shibjyoti Debnath, Sougata Sinha Ray, Zhumur Ghosh, Kaushik Biswas The definitive role of ganglioside GM2 in mediating tumor-induced growth and progression is still unknown. Here we report a novel role of ganglioside GM2 in mediating tumor cell migration and uncovered its mechanism. Data shows differential expression levels of GM2-synthase as well as GM2 in different human cancer cells. siRNA mediated knockdown of GM2-synt...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 7, 2016 Category: Molecular Biology Source Type: research
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Conclusion Altogether the results are consistent with a model whereby both constitutive and ligand-induced internalization of ErbB3 are regulated through interaction with epsin 1. General significance Internalization is an important regulator of growth factor receptor mediated signaling and the current study identify mechanisms regulating plasma membrane turnover of ErbB3. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - March 11, 2016 Category: Molecular Biology Source Type: research
