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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
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Total 69 results found since Jan 2013.
Modeling endophilin-mediated Aβ disposal in glioma cells
Publication date: Available online 4 July 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Bing Sun, Ping Fan, Meijian Liao, Yaou ZhangAbstractAutophagy dysregulation has emerged in age-related neurological diseases (Ulland et al.; Matheoud et al.; Ashkenazi et al. [[1], [2], [3]]). Alzheimer Disease (AD), the most common progressive neurodegenerative disorder, is characterized by the accumulation of amyloid-β (Aβ) plaques caused by aberrant Aβ metabolism (Qiang et al.; Sevigny et al.; Ittner et al. [[4], [5], [6]]). Glia constitute the brain immune system and ingest extracellular Aβ ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 11, 2018 Category: Molecular Biology Source Type: research
Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis
In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/−Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 5, 2018 Category: Molecular Biology Source Type: research
c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity
In conclusion, we demonstrate the novel role of c-Abl kinase in regulation of YY1's transcriptional activity, linking YY1 regulation with c-Abl tyrosine kinase signaling pathways.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 5, 2018 Category: Molecular Biology Source Type: research
Modeling endophilin-mediated Aβ disposal in glioma cells
Publication date: Available online 4 July 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Bing Sun, Ping Fan, Meijian Liao, Yaou ZhangAbstractAutophagy dysregulation has emerged in age-related neurological diseases (Ulland et al.; Matheoud et al.; Ashkenazi et al. [[1], [2], [3]]). Alzheimer Disease (AD), the most common progressive neurodegenerative disorder, is characterized by the accumulation of amyloid-β (Aβ) plaques caused by aberrant Aβ metabolism (Qiang et al.; Sevigny et al.; Ittner et al. [[4], [5], [6]]). Glia constitute the brain immune system and ingest extracellular Aβ ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 5, 2018 Category: Molecular Biology Source Type: research
Modeling endophilin-mediated A β disposal in glioma cells
Publication date: Available online 4 July 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Bing Sun, Ping Fan, Meijian Liao, Yaou Zhang Autophagy dysregulation has emerged in age-related neurological diseases (Ulland et al.; Matheoud et al.; Ashkenazi et al. [1–3]). Alzheimer Disease (AD), the most common progressive neurodegenerative disorder, is characterized by the accumulation of amyloid-β (Aβ) plaques caused by aberrant Aβ metabolism (Qiang et al.; Sevigny et al.; Ittner et al. [4–6]). Glia constitute the brain immune system and ingest extracellular Aβ for degradation via t...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 4, 2018 Category: Molecular Biology Source Type: research
Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis
In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/− Lgl1 flox/flox ) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 27, 2018 Category: Molecular Biology Source Type: research
c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity
In conclusion, we demonstrate the novel role of c-Abl kinase in regulation of YY1's transcriptional activity, linking YY1 regulation with c-Abl tyrosine kinase signaling pathways.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 26, 2018 Category: Molecular Biology Source Type: research
Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells
Publication date: Available online 7 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Risa Akizuki, Ryohei Maruhashi, Hiroaki Eguchi, Kazuki Kitabatake, Mitsutoshi Tsukimoto, Takumi Furuta, Toshiyuki Matsunaga, Satoshi Endo, Akira Ikari Chemotherapy resistance is a major problem in the treatment of cancer, but the underlying mechanisms are not fully understood. We found that the expression levels of claudin-1 (CLDN1) and 3, tight junctional proteins, are upregulated in cisplatin (CDDP)-resistant human lung adenocarcinoma A549 (A549R) cells. A549R cells showed cross-resistance to d...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - March 7, 2018 Category: Molecular Biology Source Type: research
Rab7a modulates ER stress and ER morphology
Publication date: Available online 2 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Duarte Mateus, Elettra Sara Marini, Cinzia Progida, Oddmund Bakke The Endoplasmic Reticulum (ER) is a membranous organelle with diverse structural and functional domains. Peripheral ER includes interconnected tubules, and dense tubular arrays called “ER matrices” together with bona fide flat cisternae. Transitions between these states are regulated by membrane-associated proteins and cytosolic factors. Recently, the small GTPases Rab10 and Rab18 were reported to control ER shape by regulating...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - March 3, 2018 Category: Molecular Biology Source Type: research
GRP78 protects CHO cells from ribosylation
In this study, we found that cellular AGEs accumulate in Chinese hamster ovary (CHO) cells with increased Rib concentration and administration time. Mass spectrum analysis of isolated AGE-modified proteins from cell lysates showed that glucose-regulated protein 78 kD (GRP78) is one of the main ribosylated proteins. Co-immunoprecipitation assays further confirmed the interaction between AGEs and GRP78. Compared with d-glucose (Glc), Rib produced much more AGEs in cells. In kinetic studies, the first order rate constant of LDH released from CHO cells incubated with Rib was nearly 8-fold higher than that of Glc, suggesting th...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - February 3, 2018 Category: Molecular Biology Source Type: research
Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR
Publication date: Available online 9 January 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Xiaofeng Li, Kin Lam Fok, Jinghui Guo, Yan Wang, Zhenqing Liu, Ziyi Chen, Chengdong Wang, Ye Chun Ruan, Sidney Siubun Yu, Hui Zhao, Ji Wu, Xiaohua Jiang, Hsiao Chang Chan Retinoic acid (RA) plays a pivotal role in many cellular processes; however, the signaling mechanisms mediating the effect of RA are not fully understood. Here, we show that RA transcriptionally upregulates cystic fibrosis transmembrane conductance regulator (Cftr) by promoting the direct binding of its receptor RARα to Cftr ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 9, 2018 Category: Molecular Biology Source Type: research
Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles
In conclusion, Pin1 is a fast-acting enzyme which may be utilised by cells to protect the phosphorylation state of TF in activated cells prolonging TF activity and release, and therefore ensuring adequate haemostasis. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 2, 2017 Category: Molecular Biology Source Type: research
Nerve/glial antigen (NG) 2 is a crucial regulator of intercellular adhesion molecule (ICAM)-1 expression
In this study, we demonstrate that in pericytes and glioblastoma cells intercellular adhesion molecule (ICAM)-1, an essential protein for leukocyte adhesion and transmigration, underlies a NG2-dependent expression. As shown by flow cytometry, Western blot analysis and quantitative real-time polymerase chain reaction (qRT-PCR), silencing of NG2 in human placenta-derived pericytes increased the expression of ICAM-1. Pathway analyses revealed that this is mediated by extracellular-regulated-kinases (ERK) 1/2 signaling. Moreover, leukocyte adhesion to NG2 siRNA-treated pericytes was significantly enhanced when compared to scra...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 2, 2017 Category: Molecular Biology Source Type: research
Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase
Publication date: January 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1865, Issue 1 Author(s): Marta Abrisqueta, Concepción Olivares, Cecilia Herraiz, María Castejón-Griñán, Julia Sirés-Campos, José C. García-Borrón, Celia Jiménez-Cervantes Signaling from the melanocortin 1 receptor (MC1R), a Gs protein-coupled receptor (GPCR) crucial for melanocyte proliferation and differentiation, is regulated by cytosolic β-arrestins (ARRBs). MC1R signaling is also negatively modulated by the E3-ubiquitin ligase Mahogunin Ring Finger-1 (MGRN1), whose mutation causes hyperpigmentation, c...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 2, 2017 Category: Molecular Biology Source Type: research
Muscle Lim Protein and Myosin Binding Protein C form a complex regulating muscle differentiation
Publication date: Available online 1 September 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Demetrios A. Arvanitis, Elizabeth Vafiadaki, Vasiliki Papalouka, Despina Sanoudou Muscle Lim Protein (MLP) is a protein with multiple functional roles in striated muscle physiology and pathophysiology. Herein, we demonstrate that MLP directly binds to slow, fast, and cardiac myosin-binding protein C (MyBP-C) during myogenesis, as shown by yeast two-hybrid, and a range of protein-protein interaction assays. The minimal interacting domains involve MLP inter-LIM and MyBP-C C4. The interaction is...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 2, 2017 Category: Molecular Biology Source Type: research
