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Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research
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Total 69 results found since Jan 2013.
Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron
Publication date: Available online 26 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): A-Ching Chao, Chien-Hui Chen, Ming-Hsuan Wu, Bo-Yu Hou, Ding-I YangAbstractOne neurotoxic mechanism of amyloid-beta peptide (Aβ), the major component of senile plaques in the brains of Alzheimer's disease (AD) patients, is to trigger cell cycle reentry in fully differentiated neurons. However, the detailed underlying mechanisms remain unclear. Using Aβ25-35–treated primary rat cortical neurons as the experimental system, in the present study we tested whether Aβ-induced inhibitor of differ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 26, 2019 Category: Molecular Biology Source Type: research
Neuropeptide bombesin receptor activation stimulates growth of lung cancer cells through HER3 with a MAPK-dependent mechanism
Publication date: Available online 17 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Lingaku Lee, Irene Ramos-Alvarez, Terry W. Moody, Samuel A. Mantey, Robert T. JensenAbstractDespite recent advances in treatment of non-small cell lung cancer (NSCLC), prognosis still remains poor and new therapeutic approaches are needed. Studies demonstrate the importance of the EGFR/HER-receptor family in NSCLC growth, as well as that of other tumors. Recently, HER3 is receiving increased attention because of its role in drug resistance and aggressive growth. Activation of overexpressed G-pr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 18, 2019 Category: Molecular Biology Source Type: research
Aquaporin-1 plays a key role in erythropoietin-induced endothelial cell migration
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Romina E. Maltaneri, Agustina Schiappacasse, María E. Chamorro, Alcira B. Nesse, Daniela C. VittoriAbstractWater influx through aquaporin-1 (AQP-1) has been linked to the ability of different cell types to migrate, and therefore plays an important part in processes like metastasis and angiogenesis. Since the erythroid growth factor erythropoietin (Epo) is now recognized as an angiogenesis promoter, we investigated the participation of AQP-1 as a downstream effector of this cytokine in the migra...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 31, 2019 Category: Molecular Biology Source Type: research
Lysosomal cysteine protease cathepsin S is involved in cancer cell motility by regulating store-operated Ca2+ entry
In conclusion, we have demonstrated for the first time that the lysosomal cysteine protease, CTSS, plays an important role in mediating Ca2+ homeostasis by regulating STIM1 trafficking, which leads to the suppression of cell migration and invasion.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 21, 2019 Category: Molecular Biology Source Type: research
Elevated cyclic-AMP represses expression of exchange protein activated by cAMP (EPAC1) by inhibiting YAP-TEAD activity and HDAC-mediated histone deacetylation
Publication date: Available online 28 June 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Reza Ebrahimighaei, Madeleine C. McNeill, Sarah A. Smith, Jason P. Wray, Kerrie L. Ford, Andrew C. Newby, Mark BondAbstractLigand-induced activation of Exchange Protein Activated by cAMP-1 (EPAC1) is implicated in numerous physiological and pathological processes, including cardiac fibrosis where changes in EPAC1 expression have been detected. However, little is known about how EPAC1 expression is regulated. Therefore, we investigated regulation of EPAC1 expression by cAMP in cardiac fibroblasts.El...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 29, 2019 Category: Molecular Biology Source Type: research
Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells
Publication date: Available online 17 January 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Amaia Navarro-Corcuera, María J. López-Zabalza, Juan J. Martínez-Irujo, Gloria Álvarez-Sola, Matías A. Ávila, María J. Iraburu, Eduardo Ansorena, Cristina Montiel-DuarteAbstractLiver damage induces hepatic stellate cells (HSC) activation, characterised by a fibrogenic, proliferative and migratory phenotype. Activated HSC are mainly regulated by transforming growth factor β 1 (TGFβ1), which increases the production of extracellular matrix proteins (e.g. collagen-I) promoting the progress...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 18, 2019 Category: Molecular Biology Source Type: research
Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells
In this study, we found that BLT2, a cell surface GPCR for leukotriene B4 and 12‑hydroxyeicosatetraenoic acid, is highly upregulated in KRAS mutant LOVO and SW480 colorectal cancer cells and plays critical roles in mediating proliferation through activation of phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) and subsequent upregulation of cyclin D1. Exposure to BLT2 siRNA or LY255283, a specific BLT2 inhibitor, clearly suppressed the proliferation of KRAS mutant colorectal cancer cells and markedly increased cell cycle arrest by downregulating the PI3K/Akt-cyclin D1 cascade. Xenograft tumor formation by LOVO...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 14, 2018 Category: Molecular Biology Source Type: research
Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation
Publication date: Available online 7 December 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Carolina Saibro Girardi, Diana Carolina Rostirolla, Fernanda Janini Mota Lini, Pedro Ozorio Brum, Jeferson Delgado, Camila Tiefensee Ribeiro, Alexsander Alves Teixeira, Daniel Oppermann Peixoto, Luana Heimfarth, Alice Kunzler, José Cláudio Fonseca Moreira, Daniel Pens GelainAbstractRetinoic acid (RA) promotes differentiation in multiple neurogenic cell types by promoting gene reprogramming through retinoid receptors and also by inducing cytosolic signaling events. The nuclear RXR receptors are...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 7, 2018 Category: Molecular Biology Source Type: research
The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Jolanta Wiejak, Boy van Basten, Urszula Luchowska-Stańska, Graham Hamilton, Stephen J. YarwoodAbstractExchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene, the protein product of which inhibits interleukin 6 (IL6) signalling through the JAK/STAT3 pathway. Here, for the first time, we use the non-cyclic nucleotide EPAC1 ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - November 9, 2018 Category: Molecular Biology Source Type: research
Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
Publication date: Available online 5 October 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Giovanna Butera, Raffaella Pacchiana, Nidula Mullappilly, Marilena Margiotta, Stefano Bruno, Paola Conti, Chiara Riganti, Massimo DonadelliAbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and devastating human malignancies. In about 70% of PDACs the tumor suppressor gene TP53 is mutated generally resulting in conformational changes of mutant p53 (mutp53) proteins, which acquire oncogenic functions triggering aggressiveness of cancers and alteration of energetic metabo...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 6, 2018 Category: Molecular Biology Source Type: research
Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression
This study investigated the roles of α-adducin (ADD1) and γ-adducin (ADD3) in regulating migration and invasion of non-small cell lung cancer (NSCLC) cells. ADD1 was mislocalized, whereas ADD3 was markedly downregulated in NSCLC cells with the invasive mesenchymal phenotype. CRISPR/Cas9-mediated knockout of ADD1 and ADD3 in epithelial-type NSCLC and normal bronchial epithelial cells promoted their Boyden chamber migration and Matrigel invasion. Furthermore, overexpression of ADD1, but not ADD3, in mesenchymal-type NSCLC cells decreased cell migration and invasion. ADD1-overexpressing NSCLC cells demonstrated increased ad...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - October 5, 2018 Category: Molecular Biology Source Type: research
ZIP9 but not the androgen receptor mediates testosterone-induced migratory activity of metastatic prostate cancer cells
Publication date: Available online 15 September 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Ahmed Bulldan, Joerg-Walter Bartsch, Lutz Konrad, Georgios Scheiner-BobisAbstractLNCaP cells are derived from a metastatic lesion of human prostate adenocarcinoma. They express the classical androgen receptor (AR) and ZIP9, a Zn2+ transporter that also binds testosterone and mediates signaling by interacting with G-proteins.Our results show that LNCaP cells respond to testosterone by mobilizing their migratory machinery. Their exposure to testosterone triggers the formation of lamellipodia, re...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 16, 2018 Category: Molecular Biology Source Type: research
Anoctamin-6 regulates ADAM sheddase function
We report that overexpression of ANO6 in HEK293T cells led to increased Ca2+-mediated PS-exposure that was indeed accompanied by enhanced release of AREG and TGF-alpha. The effect was not observed when cells were treated with the PKC-dependent ADAM17 activator PMA. Transformation of cells with a constitutively active ANO6 mutant led to spontaneous PS-exposure and to the release of ADAM17-substrates in the absence of any stimuli. Inhibitor experiments indicated that ANO6-mediated enhancement of substrate cleavage simultaneously broadened the spectrum of participating metalloproteinases. In complementary experiments, siRNA-m...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - August 24, 2018 Category: Molecular Biology Source Type: research
Lethal (2) giant larvae regulates pleural mesothelial cell polarity in pleural fibrosis
In this study, we observed that PMC polarity was lost in fibrotic pleura. Next we found increased Lethal (2) giant larvae (Lgl) bound with aPKC and PAR-6B competing against PAR-3A in PAR complex, which led to cell polarity loss. Then we demonstrated that Lgl1 siRNA prevented cell polarity loss in PMCs, and Lgl1 conditional knockout (ER-Cre+/−Lgl1flox/flox) attenuated pleural fibrosis in a mouse model. Our data indicated that Lgl1 regulates cell polarity of PMCs, inhibition of Lgl1 and maintenance of cell polarity in PMCs could be a potential therapeutic treatment approach for pleural fibrosis.
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 11, 2018 Category: Molecular Biology Source Type: research
c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity
In conclusion, we demonstrate the novel role of c-Abl kinase in regulation of YY1's transcriptional activity, linking YY1 regulation with c-Abl tyrosine kinase signaling pathways.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - July 11, 2018 Category: Molecular Biology Source Type: research
